Title: Anatomy and Physiology by Rod R Seeley 6th edition chapter 22 power-point
1 Anatomy and Physiology, Sixth Edition
Rod R. SeeleyIdaho State University Trent D.
StephensIdaho State University Philip
TatePhoenix College
Chapter 22 Lecture Outline
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2Chapter 22
- Lymphatic System and Immunity
3Lymphatic System
- Lymph
- Lymphatic vessels
- Lymphatic tissue
- Lymphatic nodules
- Lymph nodes
- Tonsils
- Spleen
- Thymus
4Functions of the Lymphatic System
- Fluid balance
- Excess interstitial fluid enters lymphatic
capillaries and becomes lymph - Fat absorption
- Absorption of fat and other substances from
digestive tract - Defense
- Microorganisms and other foreign substances are
filtered from lymph by lymph nodes and from blood
by spleen
5Lymphatic Vessels
- Carry lymph away from tissues
- Lymphatic capillaries
- More permeable than blood capillaries
- Epithelium functions as series of one-way valves
6Lymphatic Vessels
- Lymphatic capillaries join to form
- Lymphatic vessels
- Have valves that ensure one-way flow
- Lymph nodes Distributed along vessels and filter
lymph - Lymphatic trunks Jugular, subclavian,
bronchomediastinal, intestinal, lumbar - Lymphatic ducts Right and thoracic which connect
to large veins
7Lymph Drainage Into Veins
8Lymphatic Tissue and Nodules
- Lymphatic tissue
- Consists mainly of lymphocytes
- Encapsulated or not
- Lymphatic nodules
- Numerous in loose connective tissue of digestive
(Peyers patches), respiratory, urinary,
reproductive systems
9Tonsils
- Large groups of lymphatic nodules in nasopharynx
and oral cavity - Provide protection against bacteria and other
harmful material - Groups
- Palatine
- Pharyngeal
- Lingual
10Lymph Nodes
- Organized in cortex and medulla
- Substances removed by phagocytosis or stimulate
lymphocytes or both - Only structures to filter lymph
- Afferent and efferent vessels
11Spleen
- Located in left superior side of abdomen
- Can be ruptured in traumatic abdominal injuries
resulting in bleeding, shock, death - Blood flows through at 3 different rates
- Fast (most), slow, intermediate
- Functions
- Destroys defective RBCs
- Detects and responds to foreign substances
- Limited reservoir for blood
12Spleen
13Thymus
- Located in superior mediastinum
- Divisions Cortex and medulla
- Site of maturation of T cells
14Immunity
- Ability to resist damage from foreign substances
as microorganisms and harmful chemicals - Categories
- Innate or nonspecific resistance
- Mechanical mechanisms Prevent entry or remove
microbes - Chemical mediators Promote phagocytosis and
inflammation - Cells Involved in phagocytosis and production of
chemicals - Adaptive or specific immunity
- Specificity Ability to recognize a particular
substance - Memory Ability to remember previous encounters
with a particular substance and respond rapidly
15Mechanical Mechanisms andChemical Mediators
- Chemical Mediators
- Complement
- Group of 20 proteins
- Circulate in blood in inactive form
- Become activated in cascade form Classical or
alternative pathway - Interferons
- Prevent viral replication
- Mechanical Mechanisms
- Skin, tears, saliva, mucous membranes, mucus
16Complement Cascade
17Innate Immunity Cells
- White blood cells
- Most important cellular components of immune
system - Methods
- Chemotaxis
- Phagocytosis
- Neutrophils
- Phagocytic and first cells to enter infected
tissue
- Macrophages
- Monocytes that leave blood, enter tissues
- Large phagocytic cells
- Basophils and mast cells
- Promote inflammation
- Eosinophils
- Reduce inflammation
- Natural killer cells
- Lyse tumor and virus-infected cells
18Inflammatory Response
19Inflammatory Response
- Tissue injury regardless of type can cause
inflammation - Response initiated by chemical mediators that
produce vasodilation, chemotactic attraction,
increased vascular permeability - Types
- Local Symptoms are redness, heat, swelling,
pain, loss of function - Systemic Symptoms are increase in neutrophil
numbers, fever and shock
20Adaptive Immunity
- Involves the ability to recognize, respond to,
and remember a particular substance - Stimulants
- Antigens Large molecules
- Foreign Not produced by body, introduced from
outside - Self-antigens Produced by body
- Haptens Small molecules and capable of combining
- Types
- Humoral or Antibody-mediated B cells
- Cell-mediated T cells
21Origin and Developmentof Lymphocytes
- B and T cells
- Originate in red bone marrow
- Move to lymphatic tissue from processing sites
and continually circulate - Clones are small groups of identical lymphocytes
22Origin and Developmentof Lymphocytes
- Positive selection
- Ensures survival of lymphocytes that react
against antigens - Negative selection
- Eliminates lymphocytes that react against
self-antigens - Primary lymphatic organs (red bone marrow,
thymus) - Where lymphocytes mature into functional cells
- Secondary lymphatic organs
- Where lymphocytes produce an immune response
23Antigenic Determinants
- Antigenic determinants
- Specific regions of a given antigen recognized by
a lymphocyte - Antigenic receptors
- Surface of lymphocyte that combines with
antigenic determinant
24Major Histocompatability Complex (MHC)
- Most lymphocyte activation involves glycoproteins
of cell surfaces called MHC molecules - Class I molecules display antigens on surface of
nucleated cells, resulting in destruction of
cells - Class II molecules display antigens on surface of
antigen-presenting cells, resulting in activation
of immune cells
25Antigen Processing
26Costimulation
27Proliferation of Helper T Cells
28Proliferation of B Cells
29Lymphocyte Inhibition
- Tolerance To prevent the immune system from
responding to self-antigens - Provoked by
- Deletion of self-reactive lymphocytes
- Preventing activation of lymphocytes
- Activation of suppressor T cells
30Antibody-Mediated Immunity
- Antibodies or Immunoglobulins (Ig)
- Classes IgG, IgM, IgA, IgE, IgD
- Structure
- Variable region Part that combines with
anitgenic determinant of antigen - Constant region Responsible for activities
31Actions of Antibodies
32Antibody Production
33Cell-Mediated Immunity
- Antigen activates effector T cells and produces
memory T cells - Cytotoxic T cells lyse virus-infected cells,
tumor cells, and tissue transplants - Cytotoxic T cells produce cytokines, which
promote phagocytosis and inflammation
34Interactions and Responses ofInnate and Adaptive
Immunity
35Acquired Immunity
- Active natural immunity
- Results from natural exposure to an antigen
- Active artificial immunity
- Results from deliberate exposure to an antigen
- Passive natural immunity
- Results from transfer of antibodies from a mother
to her fetus or baby - Passive artificial immunity
- Results from transfer of antibodies (or cells)
from an immune animal to a nonimmune one
36Ways to Acquire Adaptive Immunity
37Effects of Aging
- Little effect on lymphatic system
- Decreased ability of helper T cells to
proliferate in response to antigens - Decreased primary and secondary antibody
responses - Decreased ability of cell-mediated immunity to
resist intracellular pathogens
38Immune System Problems
- Hypersensitivity reactions
- Autoimmune disease
- Severe combined immunodeficiency disease (SCID)
- Transplantation
- Acute rejection
- Chronic rejection