fish

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Walking the line of cytochrome P450 evolution

David R. Nelson
frog
fish
chick
human
2
8
(5)
1001
(282)
621
(177)
2279
(99)
1932
(97)
210
(51)
6051
(706)
JGI Tree of Life
July 18, 2006
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Human Chr 1 vs. mouse Phylogenetically Inferred
Groups synteny viewer
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Human Chr 1 vs. mouse and chicken Phylogeneticall
y Inferred Groups synteny viewer
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Human Chr 7 vs. zebrafish Phylogenetically
Inferred Groups synteny viewer
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Human Chr 5 vs. Ciona Phylogenetically Inferred
Groups synteny viewer
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Human CYP2AC1P
Xenopus CYP2AC gene cluster
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Human CYP2J2 and HOOK1
chicken CYP2J cluster and HOOK1
zebrafish CYP2P, CYP2V, CYP2AD and CYP2N gene
cluster
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Human CYP2ABFGST gene cluster
Xenopus CYP2Q gene cluster
Fugu CYP2Y1 and CYP2Y2
Zebrafish CYP2Y3
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Human syntenic region of the Xenopus CYP2AB1 gene
Xenopus CYP2AB1
zebrafish syntenic region of the Xenopus CYP2AB1
gene
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Chicken CYP2AB gene cluster
Human CYP2AB1P pseudogene
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Synteny around the CYP2W and CYP2K gene clusters
zebrafish KCNJ2 LILRA2 CYP2K gene
cluster ABCA3 fugu centa1 RNPS1
CYP2K gene cluster ABCA3 tetraodon centa1
CYP2K gene cluster
ABCA3 Xenopus centa1
CYP2W gene cluster c16orf28 chicken centa1
CYP2W gene cluster
gpr146 human centa1
CYP2W1 gpr146
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Synteny around the CYP2X gene cluster
Zebrafish Chr25 SETD6 CNOT1 CYP2X6-9
E2F4 Zebrafish Chr7 LEAP2
CYP2X10 zgc100802 GOT2 Xenopus
CNOT1 ----
zgc100802 GOT2 chicken
SETD6 CNOT1 ---- zgc100802
GOT2 human SETD6 CNOT1
---- zgc100802 GOT2
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human CYP19 and gliomedin
zebrafish CYP19 and gliomedin ortholog
Ciona CYP20 and best BLAST hit to zebrafish
gliomedin ortholog
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human chr20 with CYP8A1 (2.7 Mb region)
human chr8 with CYP7A1, CYP7B1 (16 Mb region)
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71 moss P450s with 48 additional plant sequences
Physcomitrella
patens
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Some things that seem impossible
may actually be possible
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Ill try anything once,
twice if I like it,
three times to make sure.