EFFECT OF TOPICAL MOXIFLOXACIN ON THE REDUCTION OF BACTERIAL FLORA ON THE HUMAN OCULAR SURFACE

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EFFECT OF TOPICAL MOXIFLOXACIN ON THE REDUCTION
OF BACTERIAL FLORA ON THE HUMAN OCULAR SURFACE

• Dr. Erick Mendoza Schuster
• Dr. Francisco Amparo Pulido
• Dra. Guadalupe Cervantes Coste
• Dr. Jorge Pacheco García
• Q.F.B. Virginia Vanzzini de R.
• Dr. Cecilio Velasco Barona

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Purpose

• Evaluate the effect of topical Moxifloxacin on
  the reduction of bacterial flora on the human
  conjunctiva

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Materials/Methods

• Comparative, experimental, longitudinal and
  prospective study
• 120 eyes of 60 patients
• 41 ? / 19 ?
• Mean age 62 years (28-85 years)
• 36 metabolic cataract
• 22 senile cataract
• 2 traumatic cataract

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Materials/Methods

• Inclusion criteria
• patients without ocular pathology
• patients without ophthalmic treatment
• accepted to be included in the study
• Initial cultures of conjunctival cul-de-sac were
  taken in both eyes of patients of both groups
  that served to determine the basal bacterial flora

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Materials/Methods

• Patients were randomly included in two groups
• Group 1 Patients with moxifloxacin, 1 drop
  q.i.d. for 3 days.
• Group 2 Patients with moxifloxacin, 1 drop every
  15 minutes by one hour.
• The antibiotic was used in one eye, and the
  contralateral eye was used as control
• After the treatment, a second culture was taken
  in both eyes

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Results

• The most frequent bacteria cultured in this study
  included
• Staphylococcus epidermídis
• Corynebacterium spp
• Staphylococcus aureus

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Results
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Results
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Results
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Results
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ResultsPositive Conjunctival Cultures Post
Prophylaxis
Chi square
Fisher exact test
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ResultsCFU post prophylaxis
U Mann-Whitney
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Conclusions

• No case developed postoperative infection
• S epidermidis was the most frequent opportunist
  identified
• High sensitivity of Corynebacterium spp
• 9 bacterial species were identified but without
  statistical significance
• Statistically significant reduction in S
  epidermidis with the plan of 3 days

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Conclusions

• The goal of surgical prophylaxis should be the
  reduction of ocular surface flora.
• Despite the use of antibiotics and antiseptics,
  is not possible to eradicate the bacterial flora
  in the ocular surface, but lowering the number of
  bacteria, the risk of developing endophthalmitis,
  may decrease.

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Conclusions

• We decide the use of a Fourth-generation
  quinolone as prophylactic, based on potency,
  penetration
• and safety
• A good balance between these aspects provide the
  best protection
• With post-op infections being potentially sight
  threatening, it is ideal to exceed MIC levels
  with the antibiotic concentrations in the target
  tissues

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Thank You