Results and Discussion By: Victor, Eduard and David

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Results and Discussion By Victor, Eduard
and David
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Effect of PEG400 on the Solubility of Benzoic acid

• Drug solubility is dependent on the volume
  fraction of the cosolvent
• The solubility of benzoic acid in aqueous PEG 400
  is given by
• Cs 4.4 exp(6.27X) at 37
• Cs 2.6 exp(5.41X) at 20
• X is the volume fraction of PEG 400

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Effect of Cosolvent on Mass Transfer

• The solubility of benzoic acid in 40 PEG 400
  solution
• Perfect sink conditions could easily be
  obtained due to high solubility
• The concentration solution was observed to
  increase proportionally with time
• Increased solubility by cosolvency can ease
  treatment of experimental data in future studies

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Questions and Comments