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Shitara ? ??????? ?? ?? ??? 2006 ?? ??? ????? 16
???? ?? ??????? ??? 6 ??? ?? ??? ???????? ?????
?? 7 ???? ????? ?? ???????????? ??? ????? ??
?????????? ?? ????? 180mg/m2/day ???? 3 ???
?????? ???? ??????. ??? ?? 25 ??? ??? ???? ??????
????? ?????. ?? ??? ????? 5 ???? ?? ??? ?????
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?? ??? ????? ??????? ??????. 11
4
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????????????? ????? IV ?????????? ?? ?????? ??
???? ?? 3 ???? ?? ??? ???? ?????? ?????. 3??
?????? ????? ?? ?????? ?? ???? ????? ??? ??
?????? 44 ????? ????? ?? ????????????? ?????
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?? ?????. ?? ???? ?? ?? 2 ???? ????? ?????. ??
????? ???? ?? ??????? ???? ???? ???? ?? ?? ?????
? ??? ???????????? ????? ???? ???. 12
5
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????????????? ??? ????? ?? ?? ?? ?? ????
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????? ?????? ???. 13?? ?????? ?? ??? 37 ????? ??
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???????? CNS? ?????? ???? ???. 10
6
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?????????? ?? ????? ?? ???? ????? ?? ???. 14
7
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8
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????? ??????? a0.05 ? B0.2 ? ????? ??????
0.3 ??? ?? ???? ?? ?? ???? ????? 34 ????? ???? ??
????.
???
9
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50 ???? ??? ?? ????? ?? ???? ???????? ???? ?????
?? ?? ????? ?? ?? ???? ????? ?? ???? (??? ??? 250
???? ??? ?? ???? ?? ??? ????)????? ?? ???? ?????
2???? ?????? ?? ??? ? ?? ??? ???? BMI ? HVI
?????????? ??? ??????? ? ?????? ??? ??????? ?????
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???? ????? ???????? ??? ?? ????? ????? ????? ??
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???. ???? ????? ??? ?????????? ? ???? ?? ???? ??
????? ?? ????.
10
??? ????? ? ????? ???? ??
?? ?? ??? ???? ??????? ? ???? ?? ??? ????? ?????
spss16 ???? ???????? ????? t ? ??-?? ????? ?????
????? ?? ???.
11
?????? ??????? ????? ?????
?? ???? ????? ????? ? ????? ???? ??? ???? ?? ????
?? ?? ???? ????? ??????????? ??????? ???.
12
?????

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