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NIH Grant Proposals John C. Heath, PhD Special Assistant to the Dean (Grants) Assistant Professor Biomedical Sciences College of Veterinary Medicine, Nursing

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Title: NIH Grant Proposals John C. Heath, PhD Special Assistant to the Dean (Grants) Assistant Professor Biomedical Sciences College of Veterinary Medicine, Nursing


1
NIHGrant ProposalsJohn C. Heath, PhDSpecial
Assistant to the Dean (Grants)Assistant
Professor Biomedical SciencesCollege of
Veterinary Medicine, Nursing Allied
HealthAdjunct Assistant Professor
PsychologyCollege of Arts and SciencesTuskegee
University
  • What is Required to be Funded

2
NIH
Premier research funding organization in the
World National Institutes of Health (NIH)
received 30.7 billion in 2011 (260 million
below the 2010 level) The 0.8 cut includes
210 million spread across all 27 NIH institutes
and centers and the director's office, and 50
million from a buildings account
3
NIH
4
27 NIH institutes and centers
Biostatistics Comparative Medicine Epidemiology
Molecular Carcinogenesis Molecular Genetics
Neurobiology Reproductive Developmental
Toxicology Respiratory Biology Signal
Transduction Structural BiologyToxicology
Pharmacology
5
Types of Grants
  • The following groupings represent the main types
    of grant funding provided by NIH
  • Research Grants (R series)
  • Career Development Awards (K series)
  • Research Training and Fellowships (T F series)
  • Program Project/Center Grants (P series)
  • Resource Grants (various series)

6
Research R Grants
Type Purpose of Grant
RO1 Discrete, specified, circumscribed research project NIH's most commonly used grant program No specific dollar limit unless specified in FOA Advance permission required for 500K or more (direct costs) in any year Generally awarded for 3 -5 years
RO3 NIH Small Grant Program (R03) Provides limited funding for a short period of time to support a variety of types of projects Limited to two years of funding Direct costs generally up to 50,000 per year
7
Research R Grants
Type Purpose of Grant
R15 NIH Academic Research Enhancement Award (AREA) Support small research projects in the biomedical and behavioral sciences conducted by students and faculty in health professional schools and other academic components that have not been major recipients of NIH research grant funds Direct cost limited to 300,000 over entire project period Project period limited to up to 3 years
R21 NIH Exploratory/Developmental Research Grant Award (R21) Encourages new, exploratory and developmental research projects by providing support for the early stages of project development.  Limited to up to two years of funding Combined budget for direct costs for the two year project period may not exceed 275,000.
8
Funding by NIH in 2011(RO1, R03, R15, R21)
TOPIC MECHANISM ACTIVITY TYPE STATISTIC
Applications - Number Research Grants R01 New 23,383
Awards - Funding Research Grants R01 New 1,544,937,486
Success Rate Research Grants R01 New 15 (3507)
Applications - Number Research Grants R03 New 2,858
Awards - Funding Research Grants R03 New 47,980,344
Success Rate Research Grants R03 New 19 (543)
Applications - Number Research Grants R15 New 1,349
Awards - Funding Research Grants R15 New 65,284,932
Success Rate Research Grants R15 New 14 (189)
Applications - Number Research Grants R21 New 13,127
Awards - Funding Research Grants R21 New 370,950,187
Success Rate Research Grants R21 New 13 (1707)
9
Application Process
  1. Identify the Requests for Application (RFA)
  2. Download the RFA
  3. Read the RFA
  4. Read the RFA

10
Downloading Application
  • Funding Opportunity Announcement (FOA)
  • RFA-ES-12-007
  • http//grants.nih.gov/grants/guide/rfa-files/RFA-E
    S-12-007.html

11
Downloading Application
12
Downloading Application
13
Downloading Application
14
Guide for SF424
15
SF424
16
Research PlanPage Limits
17
Research Plan
  • Significance
  • Investigator(s)    
  • Innovation
  • Approach
  • Environment

18
Enhanced Peer Review Criteria
  • SIGNIFICANCE
  • Does the project address an important problem or
    a critical barrier to progress in the field?
  • If the aims of the project are achieved, how will
    scientific knowledge, technical capability,
    and/or clinical practice be improved?
  • How will successful completion of the aims change
    the concepts, methods, technologies, treatments,
    services, or preventative interventions that
    drive this field?

19
Enhanced Peer Review Criteria
  • INVESTIGATOR(S).
  • Are the PD/PIs, collaborators, and other
    researchers well suited to the project?
  • If Early Stage Investigators or New
    Investigators, do they have appropriate
    experience and training?
  • (Check online to review your status)
  • If established, have they demonstrated an ongoing
    record of accomplishments that have advanced
    their field(s)?
  • If the project is collaborative or multi-PD/PI,
    do the investigators have complementary and
    integrated expertise
  • Are their leadership approach, governance and
    organizational structure appropriate for the
    project?

20
Enhanced Peer Review Criteria
  • INNOVATION
  • Does the application challenge and seek to shift
    current research or clinical practice paradigms
    by utilizing novel theoretical concepts,
    approaches or methodologies, instrumentation, or
    interventions?
  • Are the concepts, approaches or methodologies,
    instrumentation, or interventions novel to one
    field of research or novel in a broad sense?
  • Is a refinement, improvement, or new application
    of theoretical concepts, approaches or
    methodologies, instrumentation, or interventions
    proposed?


21
Enhanced Peer Review Criteria
  • APPROACH
  • Are the overall strategy, methodology, and
    analyses well-reasoned and appropriate to
    accomplish the specific aims of the project?
  • Are potential problems, alternative strategies,
    and benchmarks for success presented?
  • If the project is in the early stages of
    development, will the strategy establish
    feasibility and will particularly risky aspects
    be managed?
  • If the project involves clinical research, are
    the plans for 1) protection of human subjects
    from research risks, and 2) inclusion of
    minorities and members of both sexes/genders, as
    well as the inclusion of children, justified in
    terms of the scientific goals and research
    strategy proposed?


22
Enhanced Peer Review Criteria
  • ENVIRONMENT
  • Will the scientific environment in which the work
    will be done contribute to the probability of
    success?
  • Is the equipment and apparatus available to you
    sufficient to contribute to the probability of
    success?
  • Do the requisite personnel have the required
    training to operate the equipment
  • Do you have qualified collaborators to fulfill
    the functions of the study that you are unable to
    fulfill


23
Enhanced Peer Review Criteria

For information on writing these sections go
to http//www.nlm.nih.gov/ep/Tutorial.html http
//grants.nih.gov/grants/writing_application.htm
DO NOT minimize the effect of any of these
sections They are ALL pertinent to your score
24
Scoring System
25
Submitting Your Grant
  • Your grant must be submitted to grants.gov by the
    deadline stated in the RFA.
  • It must be submitted by your authorizing agent.
  • Please remember she has to have time to review
    your application for any technical errors

26
Submitting Your Grant
  • After submission your application will go through
    two electronic checks by Grants.gov and the
    funding agency.
  • Either of these can throw up ERRORS or WARNINGS.
  • Warnings are minor errors which will not stop
    your application.
  • Errors will stop your application and have to be
    corrected within 48 hours.
  • This is NOT an extra 48 hours passed the deadline
  • If you submit at the last minute and you get
    errors and it is past the deadline you will have
    to wait until the next cycle to resubmit.

27
Finally
  • Please remember what you are doing.
  • You are asking complete strangers to give you
    1000s of government money.
  • If you want them to say yes make your story
    convincing.
  • After all the government gets its money from
    taxpayers
  • In essence you are asking the person sitting next
    to you to trust you to use their hard earned
    money wisely.

28
  • Thank you
  • Any Questions

29
Useful web addresses
Types of grants http//grants.nih.gov/grants/funding/funding_program.htm
NIH Grant Tutorials http//www.nlm.nih.gov/ep/Tutorial.html
Writing Your Application http//grants.nih.gov/grants/writing_application.htm
Funding Opportunities http//grants.nih.gov/grants/guide/search_results.htm?yearactivescoperfa
Grant Writing Tips Sheets http//grants.nih.gov/grants/grant_tips.htm
The NIH R01 Toolkit http//sciencecareers.sciencemag.org/career_development/previous_issues/articles/2007_07_27/caredit_a0700106
How to Write an NIH Grant Application http//sciencecareers.sciencemag.org/career_development/previous_issues/articles/0490/how_to_write_an_nih_grant_application
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