A Guide to Understanding the Inherited Condition of PKD by Hiranandani hospital kidney

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Inside Polycystic Kidney Disease A Guide to
Understanding the Inherited Condition
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Polycystic Kidney Disease (PKD) is a genetic
condition that affects millions of people
worldwide. It is a chronic and progressive
disorder that causes fluid-filled cysts to
develop in the kidneys, leading to their
enlargement and eventual failure. PKD can also
cause cysts to develop in other organs, such as
the liver and pancreas.
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Genetic basis of PKD
PKD is caused by mutations in the PKD1 or PKD2
genes, which are responsible for producing
proteins that regulate the growth and development
of kidney cells. In these cases, there may be no
family history of the disease, as observed in a
handful of cases at the Hiranandani Hospital
Kidney Transplant. PKD affects both men and women
equally and can occur at any age, although it is
most commonly diagnosed in adults between the
ages of 30 and 50.
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Symptoms and diagnosis
of PKD
As the cysts grow larger and multiply, they can
cause several symptoms, including Abdomen back
pain High blood pressure Blood in the
urine Urinary tract infections Kidney
stones Loss of appetite
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Treatment options for
Polycystic kidney disease

• Medications to control blood pressure and reduce
  the risk of kidney damage.
• Diuretics to vacate surplus fluid from the body.
  Antibiotics to treat urinary tract infections.
• Pain medication to manage discomfort.
• Surgery to drain cysts or remove a kidney in
  severe cases.
• Dialysis or kidney transplant in end-stage kidney
  disease.

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