Omnibus Solicitation for SBIR and STTR Grant Applications Program Announcements Requests for Applica

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Omnibus Solicitation for SBIR and STTR Grant
ApplicationsProgram AnnouncementsRequests for
Applications
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Probes and Instruments for Micro-Imaging the
BrainReleased October 23, 1998 Program
Announcement No. PA-98-007
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Sponsoring NIH Institutes

• National Institute of Mental Health

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Sponsoring NIH Institutes

• National Institute of Mental Health
• National Institute on Deafness and Other
  Communication Disorders

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Application Receipt Dates

• April 1, August 1, and December 1

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Application Receipt Dates

• April 1, August 1, and December 1
• 1998, 1999, and 2000

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Application Receipt Dates

• April 1, August 1, and December 1
• 1998, 1999, and 2000
• Reactivation is anticipated

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Purpose of PA

• Tools and approaches to image the structure and
  function of subcellular elements in the nervous
  system.

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Two Thrusts for Research and Development

• Novel probes to generate signals reflecting
• processes and structures in cells of the nervous
  system

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Two Thrusts for Research and Development

• Novel probes to generate signals reflecting
• processes and structures in cells of the nervous
  system
• Novel instruments (including software) with which
  to detect and analyze those signals

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Projects Relevant to this PA

• Very small, sterically benign probes that can be
  linked genetically to proteins that play
  important roles in cell function

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Projects Relevant to this PA

• Very small, sterically benign probes that can be
  linked genetically to proteins that play
  important roles in cell function
• High speed multi-photon microscopy to track the
  movement, and quantitate the amount of probes
  reporting intracellular processes

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Duration and Award Levels

• More time

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Duration and Award Levels

• More time
• More money

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Phase I

• Maximum duration 2 years

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Phase I

• Maximum duration 2 years
• Maximum award 400,000 for both years (i.e.,
  200,000 per year, on average), total costs.

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Phase II

• Maximum duration 3 years

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Phase II

• Maximum duration 3 years
• Maximum award 1.35 million for all three years
  (i.e., 450,000 per year, on average), total
  costs.

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Phase I and II

• Maximum duration 5 years
• Maximum award 1.75 million, total costs

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Bioengineering Nanotechnology InitiativeReleased
December 2, 1999Program Announcement No.
PA-00-018
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Initiated by the Trans-NIH BioEngineering
CONsortium (BECON)
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Sponsoring NIH Institutes and Centers

• National Cancer Institute
• National Center for Research Resources
• National Eye Institute
• National Human Genome Research Institute
• National Heart, Lung, and Blood Institute
• National Institute on Aging
• National Institute on Alcohol Abuse and Alcoholism

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Sponsoring NIH Institutes and Centers

• National Institute of Allergy and Infectious
  Diseases
• National Institute of Arthritis and
  Musculoskeletal and Skin Diseases
• National Institute of Child Health and Human
  Development
• National Institute on Drug Abuse
• National Institute on Deafness and Other
  Communication Disorders

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Sponsoring NIH Institutes and Centers

• National Institute of Dental and Craniofacial
  Research
• National Institute of Diabetes and Digestive and
  Kidney Diseases
• National Institute of Environmental Health
  Sciences
• National Institute of General Medical Sciences
• National Institute of Mental Health
• National Institute of Neurological Disorders and
  Stroke
• National Library of Medicine

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Application Receipt Dates

• April 1, August 1, and December 1

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Application Receipt Dates

• April 1, August 1, and December 1
• 2000, 2001, and 2002

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Purpose of PA

• Nanotechnologies useful to biomedicine

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Definition of Nanotechnology

• The creation of functional materials, devices and
  systems through control of matter at the scale of
  1 to 100 nanometers, and the exploitation of
  novel properties and phenomena at the same scale.

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Why Nano Now at NIH?

• Nanotechnology is emerging as a field of great
  promise for biomedicine

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Why the SBIR Program?

• Nanotechnologies may form the foundation of
  significant commercial platforms

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Projects Relevant to this PA

• Development of nanofabricated barriers to prevent
  rejection of implantable materials

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Projects Relevant to this PA

• Development of nanofabricated barriers to prevent
  rejection of implantable materials
• Development of nanoparticles and nanospheres that
  enable controlled release of therapeutic agents,
  antibodies, genes and vaccines into targeted cells

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Duration and Award Levels

• More time
• More money

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Phase I

• Maximum duration 2 years

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Phase I

• Maximum duration 2 years
• Maximum award 400,000 for both years (i.e.,
  200,000 per year, on average), total costs.

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Phase II

• Maximum duration 3 years

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Phase II

• Maximum duration 3 years
• Award level 1.2 million for all three years
  (i.e., 400,000 per year, on average), total
  costs.

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Phase I and II

• Maximum duration 5 years
• Award level 1.6 million, total costs