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Human Genetics Research in Vietnam and Ethical Aspects

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Human Genetics Research in Vietnam. and Ethical Aspects. Le Dinh Luong ... Institutions Involved in Human Genetics Research. Institute of Biotechnology, NCST, Hanoi ... – PowerPoint PPT presentation

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Title: Human Genetics Research in Vietnam and Ethical Aspects


1
Human Genetics Research in Vietnam and Ethical
Aspects
The ASEAN-EU-LEMLIFE Project 24-26 January
2004, Bangkok, Thailand
  • Le Dinh Luong
  • Vietnam National University

2
Current Status of Human Genetics Research in
Vietnam
  • National Research Programs
  • 2001-2005
  • Research Institutions Involved
  • Publications 2003
  • Research and Service Areas
  • BioArchive System in Vietnam

3
National Research Programs2001-2005
  • Sequencing of mitochondrial DNA of different
    Vietnamese ethnic groups and directed
    applications.
  • Application of molecular techniques for diagnosis
    of human hereditary diseases in Vietnam.
  • Application of molecular techniques for human
    pedigree determination and for forensics in
    Vietnam.
  • Animal stem cell research for genetic
    engineering.

4
Institutions Involved in Human Genetics Research
  • Institute of Biotechnology, NCST, Hanoi
  • Nat. Inst.of Malariology, Parasitology and
    Entomology
  • Institute of Oncology, Hanoi
  • University of Natural Sciences, VNU, HCM
  • Hanoi Medical University
  • National Institute of Pediatrics, Hanoi
  • Center of Biotechnology, VNU, Hanoi
  • Pasteur Institute, HCM
  • University of Natural Sciences, VNU, Hanoi
  • Biochem. Technology Dept, Ministry of Public
    Security
  • Forensic Science Institute, Ministry of Public
    Security

5
Publications (2003)
  • 1. The Polymophism of HLA-DRB1, -DBB1 And G6PD
    Deficiency of Muong Ethnic In Hoabinh Vietnam.
    Vu Trieu An at al. Hanoi University of Medicine
  • 2. Screening 3 Case Mutated Dystrophin Gene In
    Total 11 Vietnamese Duchenne And Becker Muscular
    Dystrophy. Nguyen Duc Bach at al. Institute of
    Biotechnology, NCST, Masafumi MatsuoKobe
    University Graduate School of Medicine, Japan
  • 3. Molecular-Based Study On Breast Cancer Samples
    Of Vietnamese Patients Using Mitochrondrial
    D-loop As Genetic Markers. Nguyen Thanh Dam at
    al. Institute of Oncology
  • 4. Establisment of Ames Test And Application In
    Detection of Carcinogen, Mutagen. Huynh Ngoc Vi
    Ca at al. University of Natural Sciences, VNU,
    HCM
  • 5. Detecting G6PD Deficiency And Analyzing
    Variants of DNA Mutation of Some Individuals with
    G6PD Deficiency from Kinh, Muong, Racley, Tay,
    Katu Ethnic Groups Living in Hanoi, Hoa Binh, Hue
    and Khanh Hoa Provinces. Nguyen Thi Ngoc Dao at
    al. Institute of Biotechnology, Kaoru Nishiyama
    Kobe University School of Medicine, Japan

6
Publications 2003 (continued)
  • 6. Determination of D13S317 Allele Frequencies In
    A Group of Vietnamese. Nghiem Xuan Dung.
    Biochemistry Technology Deparment
  • 7. Identification of Remains by mtDNA Analysis.
    Le Quang Huan at al. Institute of Biotechnology,
    NCST
  • 8. Designing Expression Vector for a Gene Coding
    Antigen CD25 Specific for Blood Cancer. La Thi
    Huyen at al. Institute of Biotechnology
  • 9. DNA Fingerprinting in Vietnamese Populations
    by Sex Chromosome Located Loci. Le Dinh Luong, at
    al. Center of Biotechnology, VNU, Hanoi
  • 10. Primary Determination of Allele Frequencies
    of CSF1PO Locus in Vietnamese Populations. Ngo
    Tien Quy at al. Institute of Forensics
  • 11. Using PCR Multiplex for Forensic Analysis and
    Paternity Determination by Some Single Locus STR
    Primers. Trinh Tuan Toan. Forensic Science
    Institute
  • 12. Detection of the 30bp Deleted Mutation in
    C-Terminus of LMP1 Gene from Vietnamese
    Nasopharyngeal Carcinoma. Nguyen Van Do at al.
    Hanoi Medical University

7
Research and Service Areas
  • Genetic Testing
  • Diagnosis of Genetic Diseases
  • Genetic Counseling
  • Forensics
  • Courts

8
BioArchive System in Vietnam
  • THERMOGENESIS CORP. sold a BioArchive System to
    the Blood Transfusion Hematology Center in HCM
    City for about US200,000 (June 2000).
  • The system can be also used by the major Cord
    Blood Banks
  • The BioArchive System is the international
    standard for collecting, processing, and
    archiving cryopreserved hematopoietic stem cells
    sourced from placental/cord blood
  • Phil Coelho, CEO of THERMOGENESIS CORP. "With
    this acquisition, Vietnam is adopting the same
    state-of-the-art stem cell technology as the
    major industrialized nations"

9
The Diseases Diagnosed by Genetic Testing
  • Alpha-1-antitrypsin deficiency
  • Amyotrophic lateral sclerosis
  • Alzheimer's disease
  • Ataxia telangiectasia
  • Gaucher disease
  • Inherited breast and ovarian cancer
  • Hereditary nonpolyposis colon cancer
  • Charcot-Marie-Tooth
  • Congenital adrenal hyperplasia
  • Cystic fibrosis
  • Duchenne muscular dystrophy
  • Dystonia
  • Fanconi anemia, group C
  • Factor V-Leiden
  • Fragile X syndrome
  • Hemophilia A and B
  • Hereditary Hemochromatosis
  • Huntington's disease
  • Myotonic dystrophy
  • Neurofibromatosis type 1
  • Phenylketonuria
  • Adult Polycystic Kidney Disease
  • Prader Willi/Angelman syndromes
  • Sickle cell disease
  • Spinocerebellar ataxia, type 1
  • Spinal muscular atrophy
  • Thalassemias
  • Tay-Sachs Disease

10
The Diseases Diagnosed by Genetic Testingin
Vietnam
  • Duchenne muscular dystrophy/Becker muscular
    dystrophy (DMD severe to mild muscle wasting,
    deterioration, weakness)
  • Hemophilia A and B (HEMA and HEMB bleeding
    disorders)
  • Thalassemias (THAL anemias - reduced red blood
    cell levels)

11
Current Status of Bioethics Awareness
  • Bioethics awareness from outside
  • Knowledge of Bioethics comes from outside through
    Media (newspapers, TV programs, Radio, Internet)
  • Ethical workshops or training courses organized
    in Vietnam by joint effort with oversea experts
    or organizations
  • Information comes from International Meetings
  • Bioethics understanding is limited
  • No curriculum in schools and higher educational
    institutions
  • No regular courses through over the country
  • Religion influence is not essential

12
BIOETHICAL ISSUES In Human Genetics Research
  • Genetic Testing
  • Is genetic testing regulated?
  • Does insurance cover genetic testing?
  • Prenatal testing A modern Eugenics ?
  • Discrimination because it involves genetic tests?
  • Diagnosis of Genetic Diseases
  • Are patients being properly informed about the
    risks and limitations of genetic technology?
  • How does personal genetic information affect an
    individual and society's perceptions of that
    individual?
  • Who owns and controls genetic information and
    human materials ?

13
Government Decree on 15/02/2003 Banning Human
Cloning
  • The Vietnam government decree on 15/02/2003
    banning human cloning, surrogacy and all means of
    choosing the sex of embryos. However, animal
    cloning and stem cell research are acceptable.
  • The decree allows the application of reproductive
    technologies, such as in vitro fertilization.
  • Foreigners can use assisted reproductive
    technology services in Viet Nam, but they are
    banned from donating or receiving eggs, sperm and
    embryos.

14
What Vietnam Should Do for Bioethical Improvement?
  • Improvement of public understanding of bioethics
  • (Introduction of bioethical courses into
    secondary and high schools International and
    regional training courses Bioethics Societies
    Regular programs in Media...)
  • Vietnam should improve the public knowledge on
    modern biotechnology (to narrow the gap
    between traditional cultures and modern knowledge
    of sciences)
  • Facilitating individual right to keep personal
    her/his own genetic information
  • (Legislation system, Appropriate health care
    system...)

15
  • Thank you !
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