Amino Acid Review

1
Amino Acid Review

• Alysia Giani
• Kelly Ta

2
Objectives

• What are the 20 standard Amino Acids and
  one-letter abbreviations?
• Amino Acid Structure, including side chains
• Hydrophobicity/ hydrophilicity of each amino acid
• How does hydrophilicity relate to location of an
  amino acid in proteins?

3
Amino Acid Structure

• R
• H2N C COOH
  
• H
• R Group Classification
• - Non-polar, Polar, Aromatic, Acidic, and Basic

• Basic Structure
• (a) Carbon
• Carboxylic Acid Group
• Amino Group
• R-group Side Chain
• Determines properties of Amino Acid

4
Non-Polar Hydrophobic

• Glycine (G)
• Alanine (A)
• Proline (P)
• Valine (V)
• Leucine (L)
• Isoleucine (I)
• Methionine (M)

5
Polar Hydrophilic

• Serine (S)
• Threonine (T)
• Cysteine (C)
• Asparagine (N)
• Glutamine (Q)

6
Aromatic

• Phenylalanine (F)
• Hydrophobic
• Tyrosine (Y)
• Hydrophilic
• Tryptophan (W)
• Hydrophobic

7
Charged R-Groups

• Acidic (positively-charged)
• Aspartate (D)
• Glutamate (E)
• Basic (negatively charged)
• Lysine (K)
• Arginine (R) - strongly
• Histidine (H) - weakly

8
Amino Acid location in Protein

• Hydrophilic amino acids will be found on the
  outer surface of proteins due to their polarity
  which will form H-bonding with water molecules.
• Hydrophobic amino acids form hydrophobic pockets
  on the inside of proteins, using hydrophobic
  interactions between R-groups.