ACUTE MYELOID LEUKEMIA (AML) - PowerPoint PPT Presentation

Loading...

PPT – ACUTE MYELOID LEUKEMIA (AML) PowerPoint presentation | free to download - id: 3be5a3-ZDNlM



Loading


The Adobe Flash plugin is needed to view this content

Get the plugin now

View by Category
About This Presentation
Title:

ACUTE MYELOID LEUKEMIA (AML)

Description:

Presented by Judi McCarter Clinical Overview Acute myeloid leukemia (AML) is one of four types of leukemia. AML is cancer of the blood-forming tissue (bone marrow). – PowerPoint PPT presentation

Number of Views:2774
Avg rating:3.0/5.0
Slides: 15
Provided by: coursesCs5
Learn more at: http://courses.csusm.edu
Category:
Tags: acute | aml | leukemia | myeloid

less

Write a Comment
User Comments (0)
Transcript and Presenter's Notes

Title: ACUTE MYELOID LEUKEMIA (AML)


1
ACUTE MYELOID LEUKEMIA (AML)
Presented by Judi McCarter
2
Clinical Overview
  • Acute myeloid leukemia (AML) is one of four types
    of leukemia.
  • AML is cancer of the blood-forming tissue (bone
    marrow).
  • Normal bone marrow produces red cells, white
    cells, and platelets.
  • AML causes bone marrow to produce too many
    immature white blood cells (blast cells).
  • Suppresses normal blood cell production.
  • Anemia, leucopenia, thrombocytopenia

3
(No Transcript)
4
(No Transcript)
5
Clinical Overview
  • AML is acquired from genetic damage to the DNA of
    a single cell in the bone marrow resulting in
    malignancy.
  • Diagnosed by clinical laboratory tests performed
    on blood and bone marrow.
  • Primarily affects adults and children younger
    than one year old.
  • Incidence is 2.5 out of 100,000 people.

6
Signs and Symptoms
  • Fatigue
  • Shortness of breath on exertion
  • Easy bruising
  • Petechiae
  • Bleeding in the nose or from the gums
  • Prolonged bleeding from minor cuts
  • Recurrent minor infections or poor healing of
    minor cuts
  • Loss of appetite or weight loss
  • Mild fever

7
Statistics
  • Incidence
  • Mortality
  • Prognosis
  • Prognosis
  • Prognosis

5-year survival rate in adults over 65 is 4
20-30 experience remission or are cured
Sources American Cancer Society, 2003 The
Leukemia Lymphoma Society, 2003
8
Risk Factors
  • Age
  • Older adults are more likely to develop AML
  • Smoking
  • 20 of AML cases are linked to smoking
  • Doubles the risk of disease in people older than
    60
  • Genetic disorders
  • Down syndrome, Fanconis anemia
  • High doses of radiation
  • Long-term survivors of atomic bombs
  • Previous chemotherapy treatment
  • Breast cancer, ovarian cancer, lymphoma
  • Exposure to industrial chemicals
  • Benzene

9
Treatments for AML
  • Chemotherapy
  • Phase One Remission induction therapy
  • Phase Two Remission continuation therapy
  • Radiation therapy for certain cases
  • Bone marrow transplantation

10
Prognosis for AML
  • Survival rates greatly improved over past 25
    years.
  • Majority of patients still succumb to the
    disease.
  • Remission rates inversely related to age.
  • 5-year survival rate in adults under 65 is 33
  • 5-Year survival rate in adults over 65 is 4
  • Dependent upon several factors.
  • Age
  • White blood cell count
  • Presence of translocations in bone marrow

11
The Future
  • Clinical trials
  • New drug treatments
  • Vaccines
  • Immunotherapy
  • Leukemia type-specific therapy
  • Gene therapy
  • Block encoding instructions of an oncogene
  • Target the oncoprotein
  • Blood and marrow stem cell transplantation
  • Bone marrow transplantation provides long-term,
    disease-free survival among patients in remission

12
Jillian had leukemia. She was only one year old.
She needed a transplant, but no one in her family
was a match. Joe had joined the Registry at the
encouragement of a friend. Brought together by
the National Marrow Donor Program, this donor and
recipient now have a life-long connection. http//
www.marrow.org

13
  • 1-800-4MY-SDBB 1-800-469-7322

http//www.sandiegobloodbank.org
14
Questions??
Thank you.
About PowerShow.com