Continuous venovenous haemodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple-organ dysfunction syndrome: a multicentre randomised trial

1
Continuous venovenous haemodiafiltration versus
intermittent haemodialysis for acute renal
failure in patients with multiple-organ
dysfunction syndrome a multicentre randomised
trial
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2
Introduction

• Continuous arteriovenous haemofiltration in 1977,
  
• Reduce the time to recovery of renal function and
  even result in increased survival
• synthetic membranes replacement vs.
• intermittent H/D with cuprophan

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Introduction

• Mehta and colleagues higher death rates
• in favour of intermittent haemodialysis
• (hepatic failure, and organ system failure and
• APACHE III )gt death rates no difference
• technique , use of different membranes , the
  absence of standardisation of dialysis protocols

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Aim

• comparing with polyacrylonitrile membranes on
  survival in patients with acute renal failure as
  part of multiple-organ dysfunction syndrome.

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Method -patient

• From Oct 1, 1999, to March 3, 2003
• Prospective randomised, non-blinded trial in 21
  medical or multidisciplinary intensive-care units
  from university or community hospitals in France.

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Method -patient

• Eligibility criteria
• acute renal failure