Medical Microbiology - PowerPoint PPT Presentation

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Medical Microbiology

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Title: Author: tyl Last modified by: Lenovo User Created Date: 11/5/2001 1:07:33 AM Document presentation format: – PowerPoint PPT presentation

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Title: Medical Microbiology


1
? ? ? ? ?
? ? ? ? ? ?
Medical Microbiology
?????????????
2
?????? ??
  • ??? ?????
  • ????? ??????

3
????
??????,???????????
4
????????
  • ??????RNA???(Picornaviridae),??
  • 1???????? (poliovirus)
  • 2??????(coxsackievirus)
  • 3?????(ECHO virus)
  • 4??????
  • ???????
  • 1?????(rotavirus)
  • 2???????(calicivirus)
  • 3??????(enteric adenovirus)
  • 4?????(astrovirus)

5
??? ????
  • ?RNA???(Picornaviridae)????????
  • ??????? ?1?2?3??
  • ?????
  • A?1-22,24?
  • B?1-6?
  • ????(ECHO) 1-9,11-27,29-33?
  • ????? 68?68?70?71?

6
?????????????????
?????? ??????? ????????????
????? -
????? - -
???? - -
7
?????
  • ?? ,??2430 nm ,???????,???
  • ()ssRNA,
  • ????VP1VP4
  • ??D?C?? ??
  • ?????,????????????,???????????,???????????,???????
    ?

8
(No Transcript)
9
???????(??)
10
???????
(? ? 350,000)
11
?????
12
?????
13
???????
  • VP1?VP2?VP3?????,VP4????????
  • VP1?VP2?VP3??????????
  • VP1??????????????????
  • VP4????????????????????

14
(No Transcript)
15
?????????
  • ??
  • 90???????
  • ????????????????
  • ??????????????????,???????????????
  • ?????-???,?????????

16
????
  • ?????
  • ????
  • ????????????
  • ??????
  • ?????
  • ???????
  • ??

17
(?)?????
  • 85?1??????????
  • ????????????,?????????
  • ?????,????????

18
???????????
  • ??? ??,????,?????
  • ????????

19
??
??
????90-95, ??????,????
????????????
??
10
???????
???,5-10 ??????????? (?????)
?????????
???????
1-2
??????
??????????
20
?????????
21
(No Transcript)
22
?????????
  • 90????????
  • ?5??????(????)
  • 12?????????????????
  • ??0.1????????????
  • ??????????
  • ??? ???????????

23
????????
24
????????
25
?????????????
26
1950's?????????????
27
?????????????????????57?
28
Franklin D. Roosevelt(???? ???)
  • 1882???????
  • 1921, ??39???, ????????,???????????,?????????????
    ???
  • ??,?????????,?????????,????????????????,???1928???
    ???????
  • 1932?,???????32???,?????4?,????????????????

29
(?)????
  • ???????????,?????????????????
  • 1957???????????
  • 1958??????????
  • 1959??????????

30
???
  • ????????????????Cox A16?,1969?EV71???????????EV71?
    ??Cox A16??????,?????????????
  • ???????????(Coxasckie virus) A?16?4?5?7?9?10 ?,
    B?2?5?13 ??
  • ????(ECHO viruses)
  • ????71?(EV71)

31
??????
  • 20??70????,???????????????????????????EV71??,1975?
    ????????750?,??149???,44????
  • 1994????????Cox A16?????????,?????1-4????,????????
    ??
  • 20??90????,EV71?????????1997???????????EV71???????
    ??,4-8???2628???,4-6??29??????

32
??????
  • ???1981?????????,??,???????????????????????????10?
    ??????????
  • 1983?????Cox A16?????????,5-10?????7
    000??????2???????,1986??????
  • 1995??????????????????EV71,1998???????????????????
    ????EV71?
  • 1998?,????????EV71??????????????????,???????129106
    ?????????????405?,??78?,???5??????????????????????
    ??????????????????????

33
??????
  • ?????????25000?, 34????? ???,??5?12?,
  • ?? 14793?
  • ????????9824? ??????6188?
  • ?? 5132?

34
??????
  • ??5?12?,??????????14793?, ????7?
  • ?????21???119??(?)??????,???????????????(3156?)??
    ?(3081?)???(2001?)???(1452?)???(941?)?

35
????????
  • ??????????,??????????,??????????,??3??????????
  • ?????????????????
  • ????
  • ????????-??/?????????
  • ??????????????????????????????????????????????????
    ????????????????????????????????
  • ?????,??????????????,???????????????

36
????
37
????
38
????
39
????
  • ????,???
  • ??????????????,?????????????????????,???????
  • ???????????,?????
  • ??????????????????????????????

40
????
  • ?????????????,???????,??????????????????????
  • ??????????????????????,????????,??????????????????
    ????

41
???
  • ????????????????????,?????????????????????

42
??????
  • ?????????????????????????????????????????????????
    ?????
  • ?????????????IgM????,??????????IgG???4???????
  • ?????????????????????????????????????????????????
    ????????????????

43
??????????
  • 2000??????????????
  • ????????????????????
  • 2001?10?WHO?????????????????????????

44
??????
??????
IPV
(?????)
OPV
(???????,?????)
????????
??
????????SIgA
??????
?????
??????
45
???????????????
?? ??? (OPV)Sabin ??? (IPV)Salk ????
???? ???? ????
????????? ???? ???? ???????? ?
???????? ??? ?,????
??? ??? ????????? ?
?????(VAPP) ???? ??
?
46
??? ????(rotavirus)
  • ???????
  • ????? ????
  • ????? SRSV ? ??????
  • ???? ?????
  • ????? ????

47
?????
  • ??,6080nm ?????,???
  • ?????
  • ???????RNA??,?11???
  • ??????VP1-VP7
  • ?????????

48
????
49
?????
?????
50
??????
  • VP6?????,????????
  • VP4?VP7?????,???????,??????,VP4???????,???????????
    ???,
  • VP1-VP3????,??VP1??????,VP2????,VP3??????????

51
???????
  • A? ??????????
  • B? ???????,???????????
  • C? ???,??????
  • D--G? ???????

52
???????
  • ????????????
  • ?-??????????,???????
  • A??????,???????????????
  • ??????????,??????,??????
  • ????????SIgA,??????????

53
?????????
  • ??????????ELISA?PAGE?PCR?
  • ?????,????,????
  • ???????,???????
  • ????????????,???????

54
??? ??????
55
?????(enterrisadenovirus)
  • ?????????????
  • ?-?????
  • ????5?????
  • ?????????????????

56
????(calicivirus)
  • ??,???????,???
  • ???RNA,??ORFs
  • ????????
  • ??????
  • ???????SRSV???????

57
(No Transcript)
58
????(astrovirus)
  • ??,???????,?56??
  • ???,???RNA
  • ?-?????,???5?????,520?????
  • ??????????????

59
(No Transcript)
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