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Prostate Cancer Detection in Men with an Initial Diagnosis of Atypical small Acinar Proliferations

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Prostate Cancer Detection in Men with an Initial Diagnosis of Atypical small Acinar Proliferations Dr Charles Chabert The Wollongong Hospital – PowerPoint PPT presentation

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Title: Prostate Cancer Detection in Men with an Initial Diagnosis of Atypical small Acinar Proliferations


1
Prostate Cancer Detection in Men with an Initial
Diagnosis of Atypical small Acinar Proliferations
  • Dr Charles Chabert
  • The Wollongong Hospital

2
Definition
  • ASAP denotes the presence of suspicious glands
    with insufficient cytological or architectural
    atypia for a definitive cancer diagnosis

Bostwick et al Hum Path.1993 24819
3
(No Transcript)
4
Objective
  • Determine the clinical significance of ASAP in
    prostate biopsies

5
Methods
  • Illawarra prostate pathology data base reviewed
  • Jan 1994- Jan 2004
  • ASAP
  • Pathology reviewed
  • Clinical records obtained

6
Method
  • Study cohort 31
  • Median age 65 years (53-78 years)
  • Median PSA 7.6ng/ml (0.3-36ng/ml)

7
Results
ASAP 31
9 No further Biopsy
22 Second Biopsy
8
Results of No Repeat Biopsy
9 No repeat biopsy
Median F/U 8 78 months 1 CAP
TURP 1 Benign
9
Results
ASAP 31
9 No further Biopsy
22 Second Biopsy
10
Results of 2nd Biopsy
  • ASAP
  • 22/31

Benign 4
Prostate cancer 13
ASAP 5
Median interval between 1st 2nd biopsy 8
Months
11
Prostate Ca in 2nd Biopsy
347 (5)
448 (3)
  • 13/22
  • Prostate Cancer

459 (1)
336 (2)
437 (2)
12
Results of 2nd Biopsy
  • ASAP
  • 22/31

Prostate cancer 13
Benign 4
ASAP 5
13
Results of 3rd Biopsy
  • ASAP
  • 5
  • All Biopsied

Prostate Ca 2
Benign 2
ASAP 1
Median interval between 2nd 3rd 14 months
14
Results of 2nd Biopsy
  • ASAP
  • 22/31

Benign 4
Prostate cancer 13
ASAP 5
15
Results of 3rd Biopsy
Benign 4
CAP 437
Benign 2
ASAP 1
16
Summary
  • Subsequent CAP detection
  • 17/31 54.8
  • ASAP diagnosis mandates rebiopsy

17
Acknowledgement
  • Dr Sabar Napaki,
  • Southern Pathology, Wollongong

18

High Grade PIN
ASAP
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