Tridax procumbence-A Potent Blood Coagulant

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Tridax procumbence-A Potent Blood Coagulant

• Futane S.M., Mohite N.R., Nakat J.M.
• Shri. Shivaji college of Agri-Biotechnology,
  
• Amravati

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INTRODUCTION -

• Tridax procumbence is a widespread weed,commonly
  known as coat button in english,ekdandi or
  kambarmodi in marathi,ghamra in hindi and
  jayantiveda in sanskrit
• Botanical classification
• Kingdom Plantae
• Division Magnoliophyta
• Class Magnoliopsida
• Order Asterales
• Family Asteraceae
• Tribe Heliantheae
• Genus Tridax
• Species T. Procumbens

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ABSTRACT

• Tridax procumbence is a species of flowering
  plant in a daisy family.It occurs in tropical as
  well as subtropical regions,in all the seasons.
• It exhibits antiseptic,insecticidal and
  hair growth promoting properties.More commonly
  the plant leaves are used to check haemorrhage
  from cuts,brucies,wounds.
• It also reported to have various
  pharmacological effects and antimicrobial
  activity against bacteria,hence prevent the
  infection and stimulate wound healing.

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KEYWORDS

• Tridax procumbence,blood coagulation,aspartic
  acid,marker enzymes,alanine transamylase.

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CHEMICAL COMPOSITION AND THEIR PHYSIOLOGICAL
RESPONSE.

• Stigmasterol -antiinflametory property
• Betasitosterol-antiinflametory property
• Calcium-required for coagulation factors to bind
  to phospholipids.
• Phospholipids-required for tenase and
  prothrombinase to function.
• Marker enzymes Helps in conversion of fibrinogen
  to fibrin.
• (aspartate,transaminase,
• lactate dehydrogenase,
• alkaline phosphatase)

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MECHANISM OF BLOOD COAGULATION

• Blood clotting comes under the concept of
  haemostasis.It is the major defence mechanism
  against the blood loss and occurs due to
  different substances mainly glycoproteins
  synthesized by the liver.
• It involves two pathways
• A)Extrinsic Pathway It is the initial process
  in the clotting and involves factors that are not
  present in the blood.
• B)Intrinsic Pathway It involves the series of
  reaction participated by the factors present in
  the blood.
• The two pathways are not independent but
  they are coupled together to convert protrombin
  to thrombin and fribrinogen to fibrin clot.

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Important factors responsible for blood
coagulation.

• Fibrinogenforms clot
• Prothrombinit activates protein c and platelets.
• Tissue factorco factor of prothrombin
• Calciumhelps to bind the coagulation factor to
  phospholipids.
• Christmas factorforms tenase complex with
  antihaemophillic factors
• Hageman factor activates plasma protein.
• High mol.Wt kininogen factor support activation
  of hagemans factor
• Staurt prower factor forms prothrmbinase complex
  with labile factor
• Generation factor precipitates in final common
  clotting pathway.
• Fibrin stabilizing factor carried out cross
  links of fibrins.

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Diagram
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MATERIAL REQUIRED

• Sterile dry powder of Tridax procumbence,fresh
  blood sample without anticoagulant,test
  tubes,stopwatch,etc.

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METHOD

1. Take 2 ml of fresh blood sample in two test tubes
   without adding any anticoagulant.
2. Take one test tube as control and other as test
   sample.
3. Add 200mg of sterile dry powder of Tridax
   procumbence in test sample.
4. Do not add Tridax procumbence powder in control.
5. Note coagulation time of both samples.

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OBSERVATION

• Test sample clots earlier than control.

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RESULT

• Dry powder of Tridax procumbence helps in faster
  blood coagulation

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CONCLUSION

• Tridax procumbence have great medicinal
  properties and can be used for
• Wound healling
• Haemophillic disorders
• Bleeding disorders
• Antiinflamatory property
• Primary source of treatment in tribal areas where
  medical supervision is not available.

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References

• Dravya-gun vigyan-Dharmadhikari
• Textbook of pathology-harshmohan
• Textbook of biochemistry and human
  biology-J.P.Talwar
• Biochemistry-satyanarayan
• www.biologyforum.com
• www.sciencedictionary.com
• www.botanica.com

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• Thank You.

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