Basket Centrifuge (BCF-101) in the Insulin Production Process

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Basket Centrifuge (BCF-101) in the Insulin
Production Process

• Alexander Lai, Dominic Watson Karthik
  Rajendiran

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Location in the process
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Purpose of this step

• Removal of undesired chemicals
• Ammonium Acetate, Acetic Acid and Zinc Chloride
• Dewatering
• Savings in Freeze Drying Stage

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(No Transcript)
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Alternatives?

• Cyclone Separator (Hydroclone)
• Tubular Bowl
• Centrifuge

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Schematic of Perforated Basket Centrifuge with
Automatic Discharge
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Performance Metrics

• Capacity / Max Throughput (L/min)
• Solids Recovery ()
• Protein Yield ()

Photo Novo Nordisk
Photo Gregory Smutzer
Photo NASA
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Process Parameters

• RPM
• Temperature
• Feed Rate
• Solids Concentration in Feed

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Essence of Centrifuge Design
Efficiency
Capital Cost
Utilities Use
Throughput
Downtime
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Centrifuge Design

• Basis Batch Cake Volume 12.78 m3
• Pressure ? P Pa 0.5?L?2(R2 R2p)
• G- Force ? G n2a?2R

Vsolids 0.01278 m3
Scaling Factor 7
Vdesign 0.08946 m3
L/D 1
Centrifuge Diameter 0.485 m
Clearancecalc 0.449 m
Clearance 93
Cake thickness 0.036 m
Filtration Area 0.7382 m2
Fatigue P 240000000 Pa
Safety factor 2
Pdesign 120000000 Pa
RPMmax 5343.5
na 1
G-Forcemax 1,189.73 G
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Materials of Construction

• 5 materials were investigated
• Carbon Steel
• Stainless Steel
• Rubber lined Steel
• Bronze
• Monel

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Cost

• Area 0.738m2
• Unfactored cost 55,000
• MS 2007 Index, Location and Material Factored
  cost 146,000

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Mitsubishi HZ70L-Si
Specifications Value
Inside diameter (mm) 700
Capacity (L) 80
Filtration area (m2) 1
Maximum speed (rpm) 2200
Centrifugal effect (G) 1895
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Questions??