Cysteine Reactive Polymers Synthesized by Atom Transfer Radical Polymerization for Conjugation to Pr

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Cysteine Reactive Polymers Synthesized by Atom
Transfer Radical Polymerization for Conjugation
to Proteins Heather D. Maynard, University of
California, Los Angeles CHE-0416359
Proteins decorated with polymer chains are called
protein-polymer conjugates. These conjugates are
very important in medicine and nanotechnology
Polymers were synthesized to have one end that
reacts with proteins using a special initiator
for atom transfer radical polymerization (ATRP).
The reaction with proteins results in a
reversible disulfide bond and is specific for one
type of amino acid called a cysteine.
Graduate student Karina Heredia, postdoctoral
researcher Debora Bontempo and Maynard
Bontempo, D. Heredia, K. L. Fish, B. A.
Maynard, H. D. J. Am. Chem. Soc. 2004, 126,
15372-15373.