Promotion of life extension research via the Methuselah Mouse Prize and other methods: recent progre

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Promotion of life extension research via the
Methuselah Mouse Prize and other methods recent
progress Aubrey D.N.J. de Grey Department of
Genetics, University of Cambridge Email
ag24_at_gen.cam.ac.uk Reprints, general info
http//www.gen.cam.ac.uk/sens/
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• Structure of this talk
• Methuselah Mouse Prize news
• SENS in the media (UK, US, Europe)
• SENS on the net
• Recent offers of support
• Recent research progress
• Web resources to keep in touch

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• Structure of this talk
• Methuselah Mouse Prize news
• SENS in the media (UK, US, Europe)
• SENS on the net
• Recent offers of support
• Recent research progress
• Web resources to keep in touch

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Reminder the Methuselah Mouse Postponement and
Reversal prizes Postponement Prize awarded to
the creator of a Mus musculus whose age at death
was higher than any weve heard of
previously Prize fund (margin of victory /
new record) Reversal Prize awarded to age at
death plus age of onset of any treatment was
higher Prize calculated as above Reversal Prize
has attracted most donations so far
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• Criticisms of the PP and RP
• They reward a single mouse -- a statistical
  outlier -- so do not necessarily promote work of
  scientific significance.
• The RP might reward extension of frail lifespan
  it should only reward restoration of youth.

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• Solution The Rejuvenation Prize
• - Awarded not for an individual mouse but for a
  published study
• - Intervention must begin in second half of
  controls life
• - A range of biomarkers of aging must be reversed
  by onset
• Age achieved is mean of longest-lived 10

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June 2003 Postponement Prize inaugural award
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November 9 2003 Reversal Prize inaugural award
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November 21 2003 Rejuvenation Prize inaugural
award
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• Pledging to the MMP
• - FuturePay
• Basically a standing order, any amount
• The Three Hundred
• Pay on your own schedule, 1000 per year for 25
  years

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Growth of The Three Hundred The Methuselah
Foundation 08-01-2002 US   7,502.50 Kevin
Perrott 06-03-2003 CA   2,195.00 Immortali
ty Institute 06-03-2003 US   1,685.00 The
Longevity Meme-Reason 06-03-2003 US  
2,445.00 Maximum Life Foundation-David Kekich
06-14-2003 US   5,000.00 David Thompson
11-08-2003 JP   3,200.00 Abdias Ortiz
11-21-2003 US   1,000.00 Charles
Stallworth 12-31-2003 US   1,500.00 T.
Michael Cooper 01-17-2004 US  
1,300.00 Thor S Christensen 02-06-2004 DK
  2,095.00 Mastery Matrix-Mark G. Patterson
02-25-2004 US   95.00 Free4Life Ltd-David
Mckenzie 03-08-2004 GB   1,000.00 Robert
Moore 03-15-2004 US   1,185.00 Charles
Platt 03-18-2004 US   1,000.00 Pierluigi
Zappacosta 06-29-2004 US   1,000.00 The X
PRIZE Foundation 09-19-2004 US  
340.00 Anonymous Donor 2 09-19-2004 XX  
0.01 Life Extension Foundation 09-26-2004 XX
  1,000.00 Jim Gibbons 10-14-2004 XX
  1,000.00 Jay Daniel Fox 11-01-2004 US
  100.00 
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The joys of having geek volunteers
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• Structure of this talk
• Methuselah Mouse Prize news
• SENS in the media (UK, US, Europe)
• SENS on the net
• Recent offers of support
• Recent research progress
• Web resources to keep in touch

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• SENS and the MMP - drowning in journalists
• - UK Richard and Judy, Sunday Times, Daily Mail,
  Sunday Telegraph, Tatler, Capital Gold, several
  regional radio shows
• - US Fortune (June 04), Popular Science (Jan
  05), MIT Technology Review (Feb 05)
• - Europe Corriere della Sera, La Repubblica

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• Structure of this talk
• Methuselah Mouse Prize news
• SENS in the media (UK, US, Europe)
• SENS on the net
• Recent offers of support
• Recent research progress
• Web resources to keep in touch

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Google prominence (as at 27/11)
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• Structure of this talk
• Methuselah Mouse Prize news
• SENS in the media (UK, US, Europe)
• SENS on the net
• Recent offers of support
• Recent research progress
• Web resources to keep in touch

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• No longer just penurious geeks
• Offers recently received
• - 7 acres in Texas for proposed Institute
• time on new supercomputer
• promotion in China including website translation
• lots of air miles (but we need more)

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• Structure of this talk
• Methuselah Mouse Prize news
• SENS in the media (UK, US, Europe)
• SENS on the net
• Recent offers of support
• Recent research progress
• Web resources to keep in touch

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Highlights of recent research news
The stem cell transplantation was performed on
Oct. 12 this year and in just three weeks she
started to walk with the help of a walker The
patients lower limbs were paralyzed after an
accident in 1985 damaged her lower back and hips.
Afterward she spent her life in bed or in a
wheelchair. For the unprecedented clinical test,
the scientists isolated stem cells from umbilical
cord blood and then injected them into the
damaged part of the spinal cord. The sensory and
motor nerves of the patient started to improve 15
days after the operation and she could move her
hips. After 25 days, her feet responded to
stimulation.
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Highlights of recent research news
Zullo SJ et al. 2005, Rejuvenation Research,
submitted
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• Structure of this talk
• Methuselah Mouse Prize news
• SENS in the media (UK, US, Europe)
• SENS on the net
• Recent offers of support
• Recent research progress
• Web resources to keep in touch

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Reasons why my site doesnt have a news
section http//www.fightaging.org http//www.longe
vitymeme.org http//www.methuselahfoundation.org/n
ewsflash.asp http//www.futurepundit.com http//ww
w.betterhumans.org http//www.sageke.org http//ww
w.sagecrossroads.org http//www.longevity-science.
org http//www.grg.org
Thank you!
Apologies to all those I could not include
because of space