Antibody Drug Conjugate Linker - PowerPoint PPT Presentation

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Antibody Drug Conjugate Linker

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Antibody-drug conjugates (ADCs) combine the cytotoxic potency of a drug with the target specificity of an antibody. In the development of ADCs, the design of suitable linkers is crucial for the stable and efficient delivery of the cytotoxic drug to the target cells – PowerPoint PPT presentation

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Title: Antibody Drug Conjugate Linker


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https//www.creative-biolabs.com/adc
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(No Transcript)
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Cleavable linkers respond to physiological
stimuli inside the cell, such as acidic or
reductive enviromment, as well as certain
lysosomal enzyms.
Noncleavable linkers rely on lysosomal
proteolytic degradation of the antibody to
release the drug molecule.
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Cleavable linker
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pH-sensitive (acid-labile) linkers
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Non-cleavable linkers
Complete lysosomal proteolysis of the antibody
following internalization of the ADC is required
for suscessful release of the cytotoxic drug
using non-cleavable linkers, which retain the
linker and the amino acid that served as the
attachment site on the antibody. Compared to
cleavable linkers, noncleavable linkers have
superior stability within circulation, yet they
are also more dependent on efficient
internalization and intracellular degradation of
the antibody for effective drug activation. As a
result, ADCs with noncleavable linkers are
restricted to the antigen-positive tumor cells.
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GET IN TOUCH
CONTACT US
Creative Biolabs
Established in 2004, Creative Biolabs is highly
specialized in advanced antibody biochemistry and
engineering. With more than a decade of
exploration and expansion, our current research
and service capacity covers the entire new drug
discovery and development pipeline, ranging from
early discovery, preclinical evaluations, cGMP
manufacturing, to clinical trails.
45-1 Ramsey Road, Shirley, NY 11967, USA Tel
1-631-619-7922 Fax 1-631-207-8356 Email
marketing_at_creative-biolabs.com
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