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adc platform

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One essential part in ADC development is the synthesis of the drug-linker complex. This process is accomplished using advanced organic chemistry synthesis platform. In the meantime, the design and preparation of customized linker and payload drug modifications and derivatizations are also achieved using this technical ADC platform. – PowerPoint PPT presentation

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Title: adc platform


1
ADC Platform
https//www.creative-biolabs.com/adc/
2

ADCs are next-generation precision medicines that
target specific surface antigens and fight
diseases by delivering cytotoxic payload drugs
into the antigen-bearing cells. ADCs are trending
in immunotherapy and are believed to have high
potential and wide applications in treating
various types of cancer, fungal or bacterial
infections, cardiovascular disorders, and immune
diseases.
3
Antibody Design A variety of strategies are
prepared in antibody design and engineering to
generate new monoclonal antibodies with
accommodating conjugation chemistry sites for the
creation of ADCs. Regular site-directed
mutagenesis approaches are often used to
introduce amino acid residues such as extra Cys
for thiol-based conjugations.
4

Synthetic Chemistry One essential part in ADC
development is the synthesis of the drug-linker
complex. This process is accomplished using our
advanced organic chemistry synthesis platform
(DrugLnk). In the meantime, the design and
preparation of customized linker and payload drug
modifications and derivatizations are also
achieved using this technical platform.
5

ADC Manufacturing Large scale ADC preparation is
achieved utilizing this technical platform.
Creative Biolabs are able to manufacture
recombinant antibodies, protein conjugates, and
ADCs in cGMP certified facilities.
6
PtLnX Special platform generating ADCs using a
short non-cleavable linker with a Platinum core.
This novel short linker provides the ADC with
good blood stability and highly specialized
conjugation chemistry to the His residues.
Antibody and payload will be assessed for the
feasibility in using such platform and both in
vitro and in vivo assay systems will be applied
to evaluate the efficacy of the resulted ADC.
7
3D Cell Culture Solid tumors present a unique
challenge in the evaluation of ADC efficacy due
to the complicated penetration issues. To help
painting a more comprehensive picture of the ADC
behavior under these circumstances, 3D cell
culture systems are used tothat convert
2-deminsional cell layers into 3-deminsional cell
clusters to gain a more accurate ADC penetration
and distribution profile in the mimicking of
solid tumor micro-environment. The bystander
killing effect of an ADC can also be properly
evaluated in these cell clusters.
8
About
  • After years of pursuit for perfection, Creative
    Biolabs has established our leadership in
    targeted immunotherapy and antibody-drug
    conjugate (ADC) development. Creative Biolabs
    offers customers with comprehensive one-stop-shop
    of all aspects in ADC research and evaluation,
    ranging from antigen selection, antibody
    production/optimization, payload-linker
    synthesis, ADC conjugation, to various stages of
    ADC characterization and pre-clinical evaluation.
    Furthermore, inventory also contains an extensive
    list of linkers, payloads, payload-linker sets,
    and commonly used ADCs for quick deployment and
    concept validation.

9
Contact
  • 45-1 Ramsey Road, Shirley, NY 11967, USA
  • Email marketing_at_creative-biolabs.com
  • www.creative-biolabs.com/car-t

10
THANK YOU
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