Amino Acids Can Raise the Activity of Biological Polypeptides by over 4,000 Percent

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Amino Acids Can Raise the Activity of Biological
Polypeptides by over 4,000 Percent

• Editor Elaine
• Company Creative Peptides
• Website http//www.creative-peptides.com/
• Tel [phone]
• Emailinfo_at_creative-peptides.com

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• With the emergence of new diseases and bacteria,
  mutation of the virus, scientists need to develop
  new and more effective drugs. Swiss scientists
  have recently synthesized a kind of amino acid,
  which is able to shape the structure of the
  active polypeptides and enhance its efficacy the
  activity of biological polypeptides can be
  increased by more than 4,000 percent. This
  achievement is expected to aid the development of
  a series of new drugs.
• Drugs we currently use are mainly made of two
  substances. One substance is a naturally existed
  polypeptide, while the other is the protein. Both
  of the two substances are composed of natural
  amino acids. Regardless of the wide variety of
  polypeptides and proteins, their synthesis only
  contains 20 kinds of natural amino acids.
  Actually, each amino acid has a different
  structure and chemical properties of different
  combinations in amino acids might produce varying
  polypeptides and proteins with distinctive
  features. Until recent years, the vast majority
  of amino acid-based drugs are also made of those
  naturally existed amino acids, such as hormones,
  insulin, antibiotics, cyclosporine and the like.

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• However, the emergence of a wide range of new
  diseases and the revolution of viruses have
  indicated that scientists need to develop some
  more effective drugs. While as for this unique
  issue, the best way is directed evolution, which
  means simulating natural development in the
  laboratory to develop new polypeptides and
  proteins. Then, a group of researchers have
  developed a synthetic amino acid, with a similar
  structure as natural amino acids. And because
  cysteine has the sulfeny1 that other natural
  amino acids dont have, it can combine with
  another cysteine to form a new structure, thus
  affecting the functions of polypeptides and
  proteins.
• Researchers found that amino acids can help
  suppress an enzyme associated cancer and block
  the receptors found in neurons through being
  integrated into the structure of two biologically
  active polypeptides. The test showed that the
  drug activity has been promoted up by 40 times,
  compared with conventional drugs. Actually,
  structural diversity of peptide library is the
  key to achieving a good combination and better
  efficacy. With the new amino acid, highly diverse
  peptide structures can be realized. Bicyclic
  peptide has been regarded as the replacement of
  small molecules or large antibody in common drugs
  for the disease treatment. This new therapeutic
  polypeptides will play an important value in
  future drug design.

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• The new synthetic amino acids can enhance the
  activity of the drugs and improve their chemical
  properties to promote the efficacy. Scientists
  are also very surprised by the results. Whether
  those natural molecules can play a significant
  value in future drug design might be potential.
• Source(Read full text)
• http//www.wikigenes.org/e/pub/e/702.html