CZ5226: Advanced Bioinformatics Lecture 1: Introduction of immune systems I Prof. Chen Yu Zong Tel:

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CZ5226 Advanced Bioinformatics Lecture 1
Introduction of immune systems I Prof. Chen Yu
ZongTel 6874-6877Email csccyz_at_nus.edu.sghttp
//xin.cz3.nus.edu.sgRoom 07-24, level 7, SOC1,
National University of Singapore
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Topics

• Immunity and Immune Cells
• Types of Immune Cells
• Innate Immune System
• Adaptive Immune System

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Introduction of Immune System
The perfect world
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Introduction of Immune System
The real world
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Bacteria, Fungi, Parasites, Viruses
BACTERIA -Clostridium difficile (causes
antibiotic-associated colitis
antibiotic-associated diarrhea)
FUNGUS -Epidermophyton floccosum (causes
athletes foot)
VIRUS- Polio
PARASITE - Tapeworm
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SARS Infection
How SARS coronavirus enters a cell and reproduce
itself?
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Cells of Immune System
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Innate and Adaptive Immune system
Time after Infection
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The link between innate and adaptive immune system
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Immune surveillance
Express yourself Self or Non-self?
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Germline-encoded pattern recognition receptors
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Toll-like Receptors (TLR)
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Expression of multiple receptors on a single NK
cell surface
ACTIVATION RECEPTORS
INHIBITORY RECEPTORS
NKG2D
p58 KIR
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NK recognition of target cells
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• How does innate immunity work?

II. Components 1. Barriers 2. Cell
mediated 3. Humoral
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Barriers - Functions of epithelia in innate
immunity
Eg. Defensins
Eg. gd T, B-1 cells
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2. Cell mediated components
Phagocytosis (eg. macrophages, dendritic cells,
neutrophils) Cytotoxicity (eg. natural killer
cells, gd T cells) Cell mediated productions of
cytokines
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Functions of activated macrophages
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Phagocytosis and Intracellular killing of
microbes
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Functions of NK cells
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Cytokines of innate immunity
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Interactions of different components of innate
immunity an example
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3. Humoral component

• Examples
• Complement activation
• Defensins
• Natural antibodies

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Pathway of Complement activation
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Summary of Todays lecture

• Introduction of
• Tools include
• Sequence analysis
• Microarray data analysis (relatively new, not
  covered)
• Molecular modeling
• Computer-aided drug design