Muscle Types and Their Characteristics

1
Muscle Types and Their Characteristics
2
Skeletal Muscle Anatomy
3
Muscle Fiber Anatomy
4
Anchoring the Myofilaments
5
Sarcomere Banding
6
Contractionin a Sarcomere
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Thin and Thick Filaments of the Sarcomere
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Actin
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Thin Filament Side View
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Thin and Thick Filament Interaction
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Energetics of Troponin
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More on the Organization of the Thin Filament
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Attachment of Thin Filaments to Z-Lines
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A Schematic of Myosin
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Myosin Dimer
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"Polarity of the Thick Filaments"
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Polarity of the Myosin Power Stroke
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Arrangement of Myosin Heads Around a Thick
Filament
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Linked Allosteric Forms of a Protein
20
The Crossbridge Cycle
21
Energy and Entropy
Entropic systems change state randomly such that
the macrostate remains the same.
Organized systems change state in a decided
direction (essentially the useful work of the
system) the role of energy input to these
systems is to provide directionality.
22
Ca Regulation at the SR
23
Relative Binding Affinities of the SR-bound Ca
Pump vs. Thin Filament Bound Troponin
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Ca and Binding to Troponin
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Calsequestrin as a Ca Buffer
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Questions How is Thin Filament Regulation
Organized?
What has a greater potential activity -- Ca
gates or Ca ATPase? What has a greater
affinity -- the Ca ATPase or the calmodulin
(troponin C)?
27
Excitation-Contraction Coupling
EC coupling is defined as the events that link a
nervous system command (both contract and relax)
to the mechanical events of muscle contraction.