Goodpasture Syndrome

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Goodpasture Syndrome
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What is Goodpasture Syndrome?

• Goodpasture syndrome is a cluster of acute
  illnesses that mainly affects the lungs and
  kidneys. It involves an autoimmune disorder.
  Generally, the immune system makes antibodies to
  fight off germs.But with Goodpasture syndrome,
  the immune system mistakenly makes antibodies
  that attack the lungs and kidneys. This condition
  can quickly progress to an inflammation of the
  kidneys (glomerulonephritis) and kidney failure.
  The condition can be fatal if not quickly
  diagnosed and treated.Goodpasture syndrome most
  often occurs in people ages 20 to 30 or those
  older than age 60. It is more common in men. In
  some cases, bleeding in the lungs may occur.

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What is Goodpasture Syndrome?
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• In most cases, this disease does not cause
  lasting damage to the lungs. But kidney damage
  may be long-lasting. If the kidneys fail, kidney
  transplant or dialysis may be needed.

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What causes Goodpasture syndrome?

• Medical experts are not certain what causes this
  disease. It can run in families, so genetics may
  play a role or the disease may occur because of a
  combination of other factors.These can include
  exposure to certain chemicals, such as dry
  cleaning chemicals or the weed killer paraquat.
  Viral infections, smoking, or medicines may also
  play a role.

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How is Goodpasture syndrome diagnosed?

• Your doctor will review your health history and
  do a physical exam. Other tests include
• Blood tests - These tests look for high blood
  levels of waste products that are normally
  cleared by the kidney into the urine. Circulating
  antibodies are also found by blood tests.
• Urine tests - Protein may be found in the urine
  along with red and white blood cells, and groups
  of cells and cellular material stuck together
  (granular casts).
• Kidney biopsy - A test in which tissue samples
  are removed and checked under a microscope.
• Chest X-ray - This looks for changes to the
  lungs.

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What are the symptoms of Goodpasture syndrome?

• These are the most common symptoms of
  Goodpasture syndrome
• Lack of energy or tiring easily (fatigue)
• Nausea
• Trouble breathing
• Pale skin
• As the condition progresses, other symptoms may
  occur, including
• Coughing up blood
• Burning feeling when urinating

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What are the symptoms of Goodpasture syndrome?
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• Over time, symptoms of kidney involvement may
  occur, including
• Small amounts of blood in the urine (hematuria)
• Protein in the urine (proteinuria)
• The symptoms of Goodpasture syndrome may look
  like other conditions or medical problems. Always
  see your doctor for a diagnosis.

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What is the treatment for Goodpasture syndrome?

• Your doctor will figure out the best treatment
  for you depending on
• How old you are
• Your overall health and medical history
• How sick you are
• How well you can handle certain medicines,
  procedures, or therapies
• How long the condition is expected to last
• Your opinion or preference

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What is the treatment for Goodpasture syndrome?

• Treatment may include
• Immunosuppressive medicines - These medicines
  keep your immune system from making antibodies.
  They can also make you at greater risk for
  infections. So you may also be prescribed
  antibiotics.
• Corticosteroids - Used to decrease inflammation
  and tissue damage which helps control bleeding in
  your lungs.
• Plasmapheresis - This is a process in which blood
  plasma is extracted, cleaned of harmful
  antibodies, and then returned to your body. It is
  usually given with steroids.

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