Stilnox

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Stilnox
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Stilnox

• Industrial name Stilnox
• Generic name Zolpidem Tartrate
• Indication Short term treatment of insomnia
• Date of birth1988
• Manufactured in France by Sanofi-Synthelabo
• Entered to Israel 1993
• Distribution by Mediline
• Approved by the FDA

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Stilnox

• The incidence of insomnia increases with age.30
  of adults complain of sleep disorders.90 of
  patients in nursing homes take sleep medication
  regularly.
• The target market - adults over 60, who complain
  about sleep disorders.
• There are two main groups of sleep drugs-
  benzodiazepines and non-benzodiazepines.
• The benzodiazepines market includes Vaben,
  Bondormin, Valium, and Lorivan. The
  non-benzodiazepines market includes Imovan,
  Nocturno, Stilnox.

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Stilnox

• Stilnox appears in one presentation of 10mg.20
  tablets in two blisters.
• Dosage 1 tablet before sleep. (For adults over
  65 half tablet before sleep).
•  Stilnox is selective for O1 in GABA receptor,
  which is the specific site for sleep in the
  brain.
• Stilnox generally induces sleep within 20-30
  minutes of administration, and is recommended to
  take immediately before sleep.
• Stilnox significantly increases the mean total
  sleep time.
• Stilnox significantly reduces the number of early
  awakenings.
• Stilnox can be taken intermittently - as needed.

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Advantages of Stilnox

• Non BZD image (1st member of a new chemical
  class) O1 selective.
• Optimal half-life T1/2 21/2 hr. (long enough
  for good nights sleep, short enough for a full
  active day.
• Preserves natural sleep architecture.
• Minimal potential for dependence.
• Can be taken intermittently- as needed.
• Does not cause metal taste.
• Stilnox is a non addictive drug.

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Who may benefit from Stilnox

• Adults complaining of sleep disorders.
• A large group of untreated patients.
• Large group of patients are still treated with
  benzodiazepines and other medications.

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How to switch to Stilnox
Withdrawal
Waiting
Prescription

•  Withdrawal - stopping treatment with
  Benzodiazepine should be gradual and not sudden
• Waiting - Washout period 2-3 days depending on
  half-life of the Benzodiazepine
• Prescription of Stilnox

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Thank you