Chapter 9: Stereochemistry

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Chapter 9 Stereochemistry
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(No Transcript)
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Loius Pasteur
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Physical Properties of Stereoisomers
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Stereochemistry in Drugs

• (R)-Thalidomide
• Teratogenic
• Not a useful sedative

• Thalidomide (Europe)
• sedative
• Overdoses not fatal
• Horrible deformities when taken by pregnant women
  (teratogenic)

• (S)-Thalidomide
• Non-teratogenic
• Useful sedative

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Why is chirality important?
Chiral species fits in chiral binding site
(matched key and lock)
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Chiral species does not fit in binding site
(mismatched key and lock)