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PHARMACEUTICAL CHEMISTRY RESEARCH PROJECTS 2013

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PHARMACEUTICAL CHEMISTRY RESEARCH PROJECTS 2013; RESEARCH AREAS 1. Drug Design & Discovery (Dr. J. Joubert & Prof. S. Malan) 2. Drug Synthesis & Biological Evaluation ... – PowerPoint PPT presentation

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Title: PHARMACEUTICAL CHEMISTRY RESEARCH PROJECTS 2013


1
PHARMACEUTICAL CHEMISTRY RESEARCH PROJECTS 2013

2
RESEARCH AREAS
  • 1. Drug Design Discovery
  • (Dr. J. Joubert Prof. S. Malan)
  • 2. Drug Synthesis Biological
  • Evaluation Against pathogenic
  • Microbes (Dr. J. Joubert Prof S. Malan)
  • 4. Phytochemistry (Prof P. Eagles)

3
1. Drug design and Discovery
Neuroprotective Compounds
  • Drug design, Biological activity and
    physical-chemical properties.

Dr. J. Joubert, Prof. S.F. Malan and co-workers
4
Targets for Neuroprotection
  • Calcium homeostases
  • Calcium channels
  • NMDA receptor channels
  • Enzyme systems involved in neurodegeneration
  • Oxidative cascade,
  • NOS and MAO-B.

NOS-reaction
5
Research within drug design
  • Lead compounds
  • Chemical synthesis, drugs in use
  • New compounds from plants
  • Molecular modeling
  • Synthesis and characterization
  • Biological activity
  • In vitro
  • In vivo

6
Molecular modeling
  • Protein modeling
  • Receptor / Enzyme fit
  • Ligandfit
  • Docking

7
Synthesis and Characterisation
Synthesis and characeterization with NMR, MS and
IR.
8
Biological evaluation - In vitro In vivo
9
2. Synthesis of Novel/Hybrid Molecules
Biological Evaluation Malaria and Dengue fever
  • Inhibitory Activity
  • Resistance reversal in Microorganisms
  • Microscopic evaluation
  • Molecular Studies

10
3. PHYTOCHEMISTRY- Prof Eagles
  • Phytochemistry is the study of phytochemicals
    produced
  • in plants, describing the isolation,
    purification, identification, and
  • structure of the large number of secondary
    metabolic compounds
  • found in plants.
  • Techniques commonly used in the field of
    phytochemistry
  • Thin layer chromatography (TLC)
  • Gel (column chromatography)
  • High performance of liquid chromatography (HPLC)
  • Gas chromatography (GC)
  • Mass spectrometry
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