T??????

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?????
T??????
????
1. Immune response
?????????
Back
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?????
2. ???? ???? ?????????? ????
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?????
??????
??
Ag????? ??

• MHC ???

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????
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?????
? ??????????
1. T????????? ?????
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?????
????Ag TCR, MHC, CD3 ????B7-CD28(T)
CD40L-CD40(B) ? ? ? CD4?CD8(T) ??(anergy) ????
IL-1,IL-2,IL-4,IL-6, IL-10, IL-15,IFN-?
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?????
?????????????
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?????
2. T?????????
PTK ??????? PLC-? ???C- ? ZAP-70 ?????? PIP2 ?
?????? SH2 Src???2 PKC ????C NFAT ??T???? AP-1
????1 NF-?B B????????(????B
) MAP?? ?????????? GEF ???????
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?????
gene
????

?????
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?????
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ITAM 2?YxxL/V????Y--???,L???,V??? Y????????SH2
???????????(?ZAP-70)??,??TCR?????????
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?????
?????
gene
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?????
????
gene
Gene ?? ??
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gene
????

?????
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3. ?????T??????????
TCR-AgIL-2R (?????????) CD28-B7IL-2
???????
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CD4T??
IFN-?
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• CD8T???
• ???
• 2. ???????,?Th??IL-2???

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?????
????T?????

1. Th1

????-????(M?),????
(1)IFN-??CD40L ??M?,????IL-12,??Th1
(2)IL-3?GM-CSF ??M???
(3)IL-1?IL-6?TNF?MCP-1 ?M???????????
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Th1???????? IL-2 Th1, Th2, CTL, NK
????? IFN-? B ??IgG2a
Th1????????? ?????TNF-? ???????, ?????
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• 2. Th2
• ????????
• IL-4,5,10,13 ??B????
• ????????
• ??????, ?????????????

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• 3. Th17
• ??IL-17, ??????, ????, ??????????????????
• IL-8, MCP-1 ??, ????????????
• G-CSF, GM-CSF????????????
• IL-1?, IL-6, TNF-?, PGE2 ????

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?????
4. CTL
???????
?-MHC
MHC-?
?
??Tc
?
APC
???????

• Ag???
• MHC???

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?????
??
(1)???? ???(perforin) (??) (2)???? ??(granzyme
) TNF FasL
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?????
?????????????
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?????
?????????????
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?????
DNA??? ??
DD DED
FasLFasDD
FADD
Caspase8
??? ??
???? Apoptosis
Fas ????
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?????
?????????????
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?????
?????????????
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???T??

• ?????????, ??, ????????.
• ???CD8T????T???????????,???????????B????,??CD4T
  ??,?????????,IFN-?, IL-15.

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• CD4Th1????????,??????EAE?RA???????
• CD4Th2????????,?????????????????
• CD4Th17???????????,???????????(??????????
  RA?MS)?
• CD8CTL????????,??IV?????????????

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