Worldwide, 8th most common and 6th cancer deaths 50% pre-diagnosed metastasis (thus Not operatable) Mortality / incidence ratio: 91% Unknown pathogenesis Unknown early Dx A less studied cancer

1
???????? ?? ????? ??? ?????????

• ??? ????? ???? ???????
• ???????? ??? ?????? ????? ? ???? ??????
• ???????? ???? ?????? ?????
• 15 ???? 1394

2
(No Transcript)
3
(No Transcript)
4
(No Transcript)
5
Cancer Incidence Incidence Incidence Mortality Mortality Mortality 5-year prevalence 5-year prevalence 5-year prevalence
Cancer Number () ASR (W) Number () ASR (W) Number () Prop
6
ISLAMIC REPUBLIC OF IRAN
7
Individualized Medicine
Genomics
Proteomics
Systems Biology
8
Individualized Medicine
9
Individualized Medicine
10
Individualized Medicine
11
Individualized Medicine
12
Individualized Medicine
13
Individualized Medicine
14
(No Transcript)
15
(No Transcript)
16
(No Transcript)
17
????? ?????? ????? ?????? Reactive????? ???
???? ????? ?????????? Proactive
18
Genes Proteins in Blood
19
Systems Biology and Integration of the Data
20
?? ??????? ?? ?????? ??? ??? ?????

• Predicting Metabolism - Cellular Networks
• Predicting Disease Outcome/Prognosis
• Pathogenicity/Toxicity
• Predicting Adverse Drug Reactions
• Improving Medical Efficiency/Efficacy

21
??????? ?? ??????? ???? ?? ?????

• Novel Diagnostics
• Microchips Microarrays - DNA
• Gene Expression - RNA
• Proteomics - Protein

Novel Therapeutics Drug Target
Discovery Rational Drug Design Molecular
Docking Gene Therapy Stem Cell Therapy
Understanding Metabolism
Understanding Disease Inherited Diseases -
OMIM Infectious Diseases Pathogenic
Bacteria Viruses
22
Genome-Wide Profiling Many Ways
23
NCI / FDA CLINICAL PROTEOMICS PROGRAM
AI Pattern Discovery
24
(No Transcript)
25
Predictive Preventive

• Identification of Perturbed genetic sequences
  whole genome or Transcriptome (Exome)
• sequencing
• Identification of markers for early changes
  (Early detection)
• Identification of pathways (Prevention)
• Development of strategies for treatments
  (Individualized treatments)

26
Diagnostics

• "an annual wellness assessment by blood prick
  that will analyze 2,500 protein biomarkers, for
  an organ-by-organ report on an individual's
  health status. 2013

Ruedi Aebersold
Leroy Hood