Osseous Tissue Engineering

1

• Osseous Tissue Engineering
• Jason Mercier
• Biomedical Engineering
• September 30, 2015

2
Introduction

• Bone Tissue Reconstruction
• -Grafting
• -Scaffolding
• Materials
• Biomaterials
• Polymers
• Bone tissue cells
• Nanoparticles

3
Early History
Vittorio Putti is considered as one of the
founders of orthopedic science and bone grafting
with his earliest papers dating back to 1912
Donati et al. (2007) Acta Orthopaedica 78(1)
19-25 .
4
Biomaterials
-Biocompatible materials -Biodegradable -Non-to
xic to the body
Amini A et al. 2012 Crit Rev Biomed Eng. 40 (5)
363-408.
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Cellular Reconstruction

• Bone grafting is a very effective repair
  mechanism but there are high rates of the cells
  rejecting the graft
• Scaffolding combined with osteogenically active
  cells are very effective materials because it
  provides a great framework for the bone and
  promotes normal cellular growth

Hutmacher et al. (2000) Biomaterials. 21 2529-
2543
6
Nanoparticles
-No major surgery required in most
cases -Programmable -Can be used as the
scaffolding or in drug delivery to affected
site -Cost effective
Walmsley G. et al (2015) Institute for Stem Cell
Biology and Regenerative Medicine, Stanford
University School of Medicine 11(5) 1253-1263
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Degradable and Non-degradable
Walmsley G. et al (2015) Institute for Stem Cell
Biology and Regenerative Medicine, Stanford
University School of Medicine 11(5) 1253-1263
8
-Dramatic changes in the past couple years -The
research into new materials such as nanoparticles
has increased significantly
Amini A et al. 2012 Crit Rev Biomed Eng. 40 (5)
363-408. .
9
References
Donti D, Zolezzi C, Tomba P, Vigano A. Bone
Grafting Historical and Conceptual Review,
Starting with an Old Manuscript by Vittorio
Putti. Acta Orthapaedica 2007 78(1)
19-25. Amini AR, Laurencin CT, Nukavarapu SP.
Bone Tissue Engineering Recent Advances and
Challenges. Crit Rev Biomed Eng. 2012 40 (5)
363-408.. Hutmacher DW. Scaffolds in Tissue
Engineering Bone and Cartilage. Laboratory for
Biomedical Engineering, Institute of Engineering
Science Department of Orthopedic Surgery,
National University of Singapore 2000 21 (24)
2529-2543 Walmsley GG, McArdle A, Tevlin R,
Momeni A, Atashroo D, Hu MS, Feroze AH, Wong VW,
Lorenz PH, Longaker MT, Wan DC. Nanotechnology in
Bone Tissue Engineering. Institute for Stem Cell
Biology and Regenerative Medicine, Stanford
University School of Medicine. 2015, 11(5) 1253-
1263