NEUMIC

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NEUMIC
Project No. IST-1999-29091

• Neurons and Modified CMOS Integrated Circuits
  Interfacing

Imec The Hebrew University of Jerusalem Physics,
Chemistry,Biology
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Neuro-Electronic Synapse (NES)interact with
neuronal communication
action potential
neurotransmitter
eNES
cNES
bi-directional electrical communication
uni-directional chemical communication
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Neurons on a chip
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Recorded action potential
RAW
FILTERED (100-1500Hz)
V mV
V mV
FG tor output
time sec
time sec
intracellular voltage

• V 102uV

V 102uV
time sec
time sec
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A hybrid transducerfor molecular recognition
events
neuronal pre-synaptic element
artificial acetylcholine synapse
modulated current
electronic post-synaptic element
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cNES towards an artificial synapseAcetylCholine-
Esterase ISFET
ACh

• SAM of AChE

fast (35 sec) sensitive (10-8 M)
acetic acid
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Achievements so far, and future

• Fabrication of 1st generation experimental Si
  neuron transistor chip
• (single neurons, extended floating gate,
  depletion type,shielding metals,
• SiO2 Ta2O5)
• New package designed and realized
• (flip chip bumping, large exposure of Si area,
  easy access microscope,
• microprobes..)
• Recorded signals from stimulated neurons
  cultivated on chip
• Experimental verification of Molecular
  amplifiers based on
• chromophores
• Improved neuron adhesion layer, next to
  polylysine
• Assessment and verification of chemical sensing
  principle by direct and
• quantized measurements of ACh
• Second generation transistors designed,
  processing start end of December
• (improved S/N, improved processing, multiple
  neurons, bi-directional)
• Selection of improved surface biologization
  molecules and patterning
• Direct measurement of ACh on chip

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Conclusion
No major delays on deliverables Interactivas
tasks have been divided between
partners Expected successful completion of 3th
year if extension till December 2003, no show
stopper yet Second run and purchase of peptides,
sacharides necessary and possible after
administrative problems are solved, expected
December 2002 Agreement from project officer
obtained summer 2002
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Changes to the workplan
Second generation transistors Surface
biologization Technology implementation plan