CHMI%202227E%20Biochemistry%20I

1
CHMI 2227EBiochemistry I

• Proteins
• Secondary Structure
• Beta Strands and Beta Sheets
• Loops and Turns
• A special case Collagen

2
Beta Strands and Beta Sheets
3
Beta Sheets
4
Hydrogen Bonded Beta Strands
N
C
N
C
N
C
N
C
5
Antiparallel Beta Strands
http//dbs.umt.edu/courses/fall2006/bioc380/lectur
es/011/lecture.html
6
Parallel Beta Strands
http//dbs.umt.edu/courses/fall2006/bioc380/lectur
es/011/lecture.html
7
Mixed Beta Sheets
8
Beta Sheet Conformation
http//dbs.umt.edu/courses/fall2006/bioc380/lectur
es/011/lecture.html
9
Beta Pleated Sheets
Beta Pleated Sheets Silk
10
Loops and Turns
11
Loops and Turns
12
Loops and Turns
13
Beta turns
http//web.chemistry.gatech.edu/williams/bCourse_
Information/6521/protein/secondary_structure/beta_
turn/down/beta_turn_1.jpg
14
A special case collagen
Type I bone, tendon, fibrocartilage, dermis, cornea
Type II nucleus pulposus, hyaline cartilage
Type III intestinal and uterine wall
Type IV endothelial, epithelial membranes
Type V cornea, placenta, bone, heart valve
Found in small quantities
15
A special case collagen
16
A special case collagen
17
A special case collagen
18
A special case collagen
19
Hydrogen bonds stabilize the collagen triple helix
20
Formation of collagen fibers
21
Formation of collagen fibers
22
Collagen, Vitamin C and scurvy