Human metabolic networks

1
Human metabolic networks
2
Normal metabolic network
Noradrenaline
Adrenaline
Dopaquinone
Melanin
Dopamine
Thyroxine
Dopa
Maleyl- acetoacetate
Tyrosine
Hydroxy- phenylpyruvate
Phenylalanine
Homogentisic acid
Tyramine
Prephenate
Phenylpyruvate
3
Alkaptonuria
Noradrenaline
Adrenaline
Dopaquinone
Melanin
Dopamine
Thyroxine
Dopa
Maleyl- acetoacetate
Tyrosine
Hydroxy- phenylpyruvate
X
Phenylalanine
Homogentisic acid
Tyramine
Prephenate
Phenylpyruvate
4
Normal metabolic network
Noradrenaline
Adrenaline
Dopaquinone
Melanin
Dopamine
Thyroxine
Dopa
Maleyl- acetoacetate
Tyrosine
Hydroxy- phenylpyruvate
Phenylalanine
Homogentisic acid
Tyramine
Prephenate
Phenylpyruvate
5
PKU (phenylketonuria)
Noradrenaline
Adrenaline
Dopaquinone
Melanin
Dopamine
Thyroxine
Dopa
Maleyl- acetoacetate
Tyrosine
Hydroxy- phenylpyruvate
Phenylalanine
X
Homogentisic acid
Tyramine
Prephenate
Phenylpyruvate
6
Normal metabolic network
Noradrenaline
Adrenaline
Dopaquinone
Melanin
Dopamine
Thyroxine
Dopa
Maleyl- acetoacetate
Tyrosine
Hydroxy- phenylpyruvate
Phenylalanine
Homogentisic acid
Tyramine
Prephenate
Phenylpyruvate
7
Tyrosinase-negative albinism
Noradrenaline
Adrenaline
X
Dopaquinone
Melanin
Dopamine
X
2 possibilities
Thyroxine
Dopa
Maleyl- acetoacetate
Tyrosine
Hydroxy- phenylpyruvate
Phenylalanine
Homogentisic acid
Tyramine
Prephenate
Phenylpyruvate