PATHOPHYSIOLOGY OF INFLUENZA

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PATHOPHYSIOLOGY OF INFLUENZA
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Pathophysiology

• Binding and destruction of epithelial cells from
  nasopharynx to alveoli

Aymard M. Vaccine 1995 4770.
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Uncomplicated influenza
Kilbourne ED. Influenza. New York Plenum Medical
Book Company 1987 156218.
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Overview clinical symptoms

• Abrupt onset of symptoms
• Abrupt onset of fever, drop in temperature after
  2 days, increase again
• Severe myalgia
• Sore throat
• Dry cough
• Retrosternal pain
• Severe malaise lasting several days

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Symptoms of influenza
Nicholson KG et al., eds. Textbook of Influenza.
Malden, Massachusetts Blackwell Science 1998.
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Fulminant influenza

• Reported during pandemics
• The fulminant form can affect everyone
• Pulmonary manifestation
• Antibiotics are ineffective
• Influenza viral pneumonia

Fever Cough Dyspnoea Cyanosis
DEATH
Aymard M. Vaccine 1995 4770.
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By courtesy of APACIAsia-Pacific Advisory
Committee on influenzawww.apaci-flu.com