Antiatherosclerotic Drugs

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Antiatherosclerotic Drugs
???? ??? Tel [phone]
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???? (?)????
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Classification of hyperlipoproteinemia and drug
treatment
Type lipoprotein Ch TG AS risk drug
treatment elevated I CM
NE none
IIa LDL NE high
HMG-CoA reductase inhibitors

IIb LDLVLDL high
fibrates, HMG-CoARI III
moderate fibrates, IV
VLDL moderate fibrates,
V VLDL NE
none CM VLDL
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(?)???????????
1. ????(Lipid-lowering drugs )
(1)??????? HMG-CoA??????
????(lovastatin)?????(sinvatatin)
(2)?????????????????
????(colestyramine) (3)?????????????
???????(clofibrate),????(gemfibrozil)
?????(nicotinic acid)
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????(Lipid-lowering drugs )
?. ?????????A?????? (HMG-CoA reductase
inhibitor, ???, statins)
????(lovastatin) ???????
????????????????????
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• ????(lovastatin)
• ??????
• ????????????
• ?????????1 6????????
• ?????? ??????????????,???????????????????????????
  ??
• ??????????

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?.???????(bile acid bindidng resin)
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????(cholestyramine) ?????? ??IIa????????
?????HMG-CoA????????? ???47???,2????????
?????? ??, ??, ??? ???????????,
???????????
???????? ??????????????????????????????????????
?1?????4?????
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?.???(nicotinic acid, niacin)
????????????? ????????????
1.????????????????TG,VLDL,LDL ? 2. HMG-CoA????
???????? ?????? HMG-CoA??????
? LDL-????69? 3. HDL-???? 4.
????????????
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• ???(nicotinic acid)
• ?????? II?III?IV?V?????,
• ???????????
• ??????
• ?????????????????,????????????
• ????????????????

3. ?????????? 4. ?????????????????????
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?.???? (fibric acid)
????(gemfibrozil),???(clofibrate,
???),????(fenofibrate),????(ciprofibrate),????(ben
zafibrate)
?????????????
????????? 1??????????, ???????TG??, 2?????????????
?, ?????VLDL??? 3?????TG??,????HDL?
---???VLDL????????
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????(gemfibrozil) ?????? ????IIa?IIb?IV???????? ?
????????????VLDL??IDL??TG???
?????? ??????????????,????????
????????????????,????????
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??????????(probucol,???)
????????? ???????????? 1???????????OX-LDL??,??OX-L
DL???? 2?????,????????????????
???????????????????
?????? 1????????, 2???????????,????????
3?????????,??????????
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?????????? (??????,polyunsaturated fatty
acid,PUFA)
??????????????? ????????????????
?-6??????-????,???????
?????????????????????,
? -3??-???????PUFA??????(EPA)
? ???????(DHA)?,?????????
????????(???????????)
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??????(PUFA) 1??????????????????????
???????????????? 2?N-3?????????,???????? ??????
???II??????????????????
?????? ??????????????????