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Biomaterials, Drug Delivery, Nanotechnology and Bioengineering

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Title: Biomaterials, Drug Delivery, Nanotechnology and Bioengineering


1
Biomaterials, Drug Delivery, Nanotechnology and
Bioengineering
  • Nicholas A. Peppas
  • Center for Biomaterials, Drug Delivery,
    Bionanotechnology
  • and Molecular Recognition
  • Departments of Chemical Engineering, Biomedical
    Engineering,
  • and Division of Pharmaceutics
  • The University of Texas at Austin
  • Austin, Texas 78712, USA

2
Smart Drug Delivery
  • The future of drug delivery systems will involve
    smart systems
  • These will address the issue of keeping the drug
    at the desired therapeutic level in the body thus
    avoiding frequent administration
  • Systems use detection of chemical signals in the
    body to prompt the release of drugs
  • The ultimate goal is to administer drugs at the
    right time, at the right dose anywhere in the
    body with specificity and efficiency

3
Oral Delivery of Proteins
  • Challenges
  • Protection of the drug from
  • The acidic environment in the stomach
  • Degradation by proteolytic enzymes in the GI
    tract
  • Penetration and absorption of drug across the
    intestinal mucosa and epithelium

4
Complexation and pH Responsive Hydrogels
Complexed Small mesh size Low pH
Protect drug
Release drug
Uncomplexed Increased mesh size High pH
x
5
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6
In Vivo Study with pH-Responsive Complexation
Hydrogels
  • P(MAA-g-EG) microspheres loaded with insulin
  • Administered to diabetic rats? 40 drop in blood
    glucose levels

7
NIH 2-3 positions
8
NIH/NCI 1-2 positions
9
NSF 1 position
10
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11
System-Responsive TherapyControl-Based Design
of Biomedical Systems Configurational Biomimetic
Imprinting
Making artificial locks for molecular keys
  • Molecular key
  • (template molecule)
  • Small molecules
  • Drug substances, amino acids, steroid hormones
  • Large molecules
  • Nucleic acids, proteins
  • Cells and viruses
  • Lock
  • (polymer building blocks)
  • Functional monomers
  • Cross-linkers

12
Configurational Biomimetic Imprinting
Polymerization
Template
Extraction and drying
13
BioMEMS Sensor Platform
  • Pattern environmentally responsive hydrogels onto
    silicon microcantilevers to create a BioMEMS/MEMS
    sensor device.

14
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15
System-Responsive TherapyA Bright Future
  • Need for advanced intelligent materials, more
    reliable devices, miniaturized systems
  • Society asks for improved treatment of disease,
    advanced detection and therapy, and cost
    effective processes
  • Improvement of quality of life is important

16
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17
David
Bill
Cody
Brandon
Maggie
Diane
Jenny
Amey
Mary
Cancer
Insulin
siRNA
Recognitive
External Triggering
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