Oriana Hoi Yun Yu, Kristian B. Filion, Laurent Azoulay, Valerie Patenaude, Agnieszka Majdan, and Samy Suissa

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Oriana Hoi Yun Yu, Kristian B. Filion, Laurent
Azoulay, Valerie Patenaude, Agnieszka Majdan, and
Samy Suissa
Diabetes Care Volume 38 277-284 February, 2015
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STUDY OBJECTIVE  

• To determine whether the use of incretin-based
  drugs is associated with an increased risk of
  congestive heart failure (CHF) in type 2 diabetes
  patients

Yun Yu O. H. et al. Diabetes Care 201538277-284
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STUDY DESIGN AND METHODS

• U.K. Clinical Practice Research Datalink was used
  to conduct a cohort study with a nested
  case-control analysis
• Patients were newly prescribed antidiabetic drugs
  and had no prior history of CHF
• Study was between 1 January 2007 and 31 March
  2012

Yun Yu O. H. et al. Diabetes Care 201538277-284
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STUDY DESIGN AND METHODS

• Case subjects were defined as patients
  hospitalized for a first CHF
• Subjects were matched with up to 20 control
  subjects on age, duration of treated diabetes,
  calendar year, and time since cohort entry
• Conditional logistic regression was used to
  estimate odds ratios (ORs) with corresponding 95
  CIs of incident CHF comparing current use of
  incretin-based drugs with current use of two or
  more oral antidiabetic drugs

Yun Yu O. H. et al. Diabetes Care 201538277-284
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Yun Yu O. H. et al. Diabetes Care 201538277-284
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RESULTS

• Cohort consisted of 57,737 patients followed for
  a mean of 2.4 years
• 1,118 incident cases of hospitalized CHF were
  identified
• Current use of incretin-based drugs was not
  associated with an increased risk of CHF
• Secondary analyses revealed no duration-response
  relationship

Yun Yu O. H. et al. Diabetes Care 201538277-284
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Yun Yu O. H. et al. Diabetes Care 201538277-284
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CONCLUSIONS

• Incretin-based drug use was not associated with
  an increased risk of CHF among patients with type
  2 diabetes
• Findings provide some reassurance, but will need
  to be replicated in other large-scale studies

Yun Yu O. H. et al. Diabetes Care 201538277-284
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Yun Yu O. H. et al. Diabetes Care 201538277-284
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Yun Yu O. H. et al. Diabetes Care 201538277-284