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Monday, 21 September Chapter 11 The Endocrine System

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Class organization, intro to homeostasis. ... Chapter 11 The Endocrine System Classes of hormones The adrenal gland Fates of hormones – PowerPoint PPT presentation

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Title: Monday, 21 September Chapter 11 The Endocrine System


1
Monday, 21 SeptemberChapter 11 The Endocrine
System
  • Classes of hormones
  • The adrenal gland
  • Fates of hormones
  • Renin-Angiotensin-Aldosterone System
  • Control of hormone secretion
  • Hormone interactions (permissive effects)
  • Hypothalamus Pituitary
  • The story of Aunt Dot
  • Endocrine disorders (lab)

2
What happens to hormones once released?
Be able to give Examples.
Ex Renin
Fast if free Slow if bound
3
Renin-angiotensin-aldosterone
Renin is released from kidney cells into
bloodstream, its target in a plasma protein.
Renin
Angiotensinogenfrom liver, a plasma protein
Angiotensin I
Angiotensin converting enzyme (ACE)
Angiotensin II
Thirst
Zona Glomerulosa of Adrenal Cortex
Arterial smooth muscle vasoconstrictionincrease
blood pressure
Aldosterone
Promotes Na retention in Kidney
4
Renin from Juxtaglomerular cells in Kidney
(-)
Multi-step process involving Angiotensin I and II
Aldosterone
Angiotensin II
K in plasma
Na reabsorption in kidney
thirst
Drink
vasoconstriction
5
What happens to hormones once released?
Be able to give Examples.
Ex Renin
Fast if free Slow if bound
6
Factors that affect hormone secretion
Integrator!
Recall example beta cells of Islets of
Langerhans
Secretion is usually pulsative, may be diurnal.
7
(No Transcript)
8
Fig. 11.08
Permissive effect
Thyroid hormone stimulates production of
beta-adrenergic receptors
9
Questions so far?
10
Fig. 11.12a
11
Fig. 11.12b
NeurohypophysisAdenohypophysis
Vasopressin ( Antidiuretic hormone)Oxytocin
12
Typical Blood Flow
Artery arteriole- capillary venule- vein
heart
Portal System
Artery arteriole- capillary portal vessel
capillary venule- vein heart
  1. Hypothalamo-hypophyseal portal system
  2. Hepatic portal system
  3. Vasculature of nephrons

13
Tropic hormones control the function Trophic
hormones promote survival and growth of targets
Hypothalamo-hypophyseal portal system
14
Who Cares?
15
MenopauseWidmaier text p. 694
  • Onset age 50
  • Irregular menstrual cycles
  • Breasts and genital organs gradually atrophy
  • Decrease in bone mass strength (osteoporosis)
    (bone resorption greater than bone deposition)
  • Hot flashessweating, etiology unknown
  • Increased incidence of coronary artery disease
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