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1
Excellent percutaneous absorption of
Hirudoid????????

Fast and continuous absorption of MPS directly at
the site of the disorder????-???????????????????
Therapeutically effective concentrations of MPS
even in the subcutis???????????????????????? Pene
tration of MPS into the lower corium and the
subcutis 37 and 51 times better, respectively,
than heparin??????????????,???????????????????37?
?51?


2
Definite proof of percutaneous absorption of
MPS ?????????????????
The efficacy of a local therapeutic agent in
diseased tissue depends basically on its
absorption. The percutaneous absorption of the
active ingredient MPS has been proven in various
studies with direct and indirect
methods.??????????????????????????????????????????
?????????????????? Stüttgen et al. reported the
results of a highly interesting pharmacological
study in humans Punched samples of different
specimens of human skin were treated with tritium
labelled MPS and heparin. The skin samples were
fixed into a perfusion chamber. Perfusion fluid
and skin were analysed 180 and 360 min later.
Stüttgen ???????????????????,?????????????????????
?????,???????????????????????????????,180?360?????
???????????? The results not only confirmed the
absorption of MPS but also showed that MPS
reaches the individual dermal layers in
therapeutically effective concentrations. The
penetration rates of MPS greatly exceeded those
of heparin.??????????????????,????????????????????
????????,??????????????????
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Ratio of the MPS and heparin concentrations (in
microgram per gram tissue) in the different
dermal layers after cutaneous administration of
cream preparations, calculated to the same
concentrations of active substance (0,35
weight). (according to Stüttgen et al.)
??????????????????????????(ug/g),?????(???0.35)??
???????????(??Stüttgen???????)
Literature Stüttgen, G., Panse, P., Bauer, E.
Arzneim.-Forsch./Drug Res. 40 (I), 4, 484, (1990)
Hirudoid Cream/Gel Composition 100g of
cream/gel contain Mucopolysaccharide
polysulfuric acid ester 300mg, corr. to 25000 U.,
determined by means of the activated partial
thromboplastin time (APTT). Other ingredients
Cream Glycerol, potassium stearate, wool wax
alcohol ointment, emulsifying cetostearyl
alcohol, myristyl alcohol, isopropyl alcohol,
parabenes (E 218, E216), thymol, purified water.
Gel Isopropyl alcohol, polyacrylic acid,
propylene glycol, fragrance, sodium hydroxide,
purified water. Indications Cream Superficial
phlebitis and venous thrombosis, inflammation of
varices, treatment of varicosclerosation,
haematoma, swellings, loosening of hard scars,
improvement of scar formation after injuries,
burns, operations, etc. Gel Extensive treatment
of varices, phlebitis and venous stasis,
contusions and bruises, swellings, haematoma and
reactive effusions.Contraindications
Hypersensitivity to one of the ingredients. Side
effects In single cases hypersensitivity
reactions of the skin. Mode of administration and
dosage Hirudoid Cream should be applied once
or twice daily, if necessary more often.
Hirudoid Gel should be applied several times
daily and distributed gently. Hirudoid gel
contains alcohol and should therefore not be
brought into contact with open wounds, the eyes
or mucous membranes. The gel should not be
applied under a dressing. Hirudoid Cream/Gel
Depending on the size of the area to be treated,
a length of about 3-5cm of cream/gel is usually
sufficient. Hirudoid Cream Contact to injured
skin, the eyes or mucous membranes is to be
avoided. Hirudoid Cream/Gel should be used until
complaints have subsided. Hirudoid Cream/Gel
has also proven to be value in combination with
physiotherapy such as massage, phono- and
iontophoresis (the cream has to be applied under
the cathode).