Gray (1997), ?? ??????????? James Rayn, 16.04.08. Moscow - PowerPoint PPT Presentation

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Gray (1997), ?? ??????????? James Rayn, 16.04.08. Moscow

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Title: Gray (1997), ?? ??????????? James Rayn, 16.04.08. Moscow


1
?????? ? ????? ??????????? ?????????? ?
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  • ????????? ?.?.

2
?????????? ???????????? ? ?????? ??
???????????????
Gray (1997), ?? ??????????? James Rayn, 16.04.08.
Moscow
3
?????? ??????????? ?????????? - ???????????
  • ??????? ?????? ??????????? ?????????? ????????
    ?????????????? ???, ???????????? ???????? ?
    ???????????????, ????????? ?????? ???????
    ?????????????? ???????????, ??????????,
    ????????????? ? ????????? ???????? ?
    ???????????????
  • Jonsson E, Banta HD, Henshall C, Sampietro-Colom
    L. Summary report of the ECHTA/ECAHI project.
    International Journal of Technology Assessment in
    Health Care 2002 1821837.
  • ???? ?????? ??????????? ?????????? ??????????? ?
    ?????????????? ?????????? ??? ???????????
    ??????????, ??????????? ???????? ???????????????
    ? ?????? ??????? ????????? ??????? ? ??????????
    ????????? ?????????
  • EUNetHTA (2007)

4
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5
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6
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    ???????? ? ?? CD
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    ???????????? ?????????? ??????? ????? ???,
    ??????????? ???????

7
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8
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  • ???????????? ????????? ??????? ?????? ??
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    ???????????? ??????? ?? ???????????? ? ??????????
    ????????? ??? ?????? ?????????????.

9
???? ?????? ??????????? ??????????
  • ? 2006 ???? ??? ???????? ???????????? ??????
    ??????????? ????????????? ??????? ?
    ?????????????? ??????? ???????? (???, VEN,
    ????????? ??????).
  • ??? ???????? ????????? ????????????? ??????????
    ???????? ????????????, ??????????, ??????????,
    ?????-???????? ???????, ???????????, ?????????,
    ?????? ???????????? ? ??????.

10
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  • ???????????? 0,9,
  • ?????????? 0,8,
  • ?????????? 0,7,
  • ?????-???????? ??????? 0,5,
  • ??????????? 0,4,
  • ????????? 0,4.
  • ????? ? 80 ????? ???????? ???????? ??
    ????????????? ?????????. ??????? ???????? ?
    ?????????????.

11
?????????? ????????? ?????? ? ? ?
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  • ???????????-2.
  • ??????????? ?? ?????? ?? ????? ???????, ??????
    ??????? ????????? ???????? ? ?? ????????????? ?
    ???????????????? ?????????????.

12
  • ? ?????? ?????? ??? ??? ??????? ????? ??????
    ?????? ??????????? ???????? (???, VEN, ?????????
    ??????)!

13
???? ??????????? ??????? (?? www.rspor.ru)
  • ???????????????? (???????, ?????????????,
    ????????, ???????)
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14
??????????? ??????????? ??????? ?? ?????????????
??
  • ???, ?????????????????????? ??????, ????????? ???
    ?????????? ?? ?????????? ??.
  • ??????? ????????? ? ??????? ?????, ??????? ????
    ???????????? ???????? ????.
  • ??????????????? ?????? ? Medline, ???????????
    ???????????? ??????????? ? ?????? ?????????? ?
    TRIP Database.
  • ? ?????? ?????????? ?????????????????
    ?????????????? ???????????? ? Medline.

15
??????????? ???????? ???????
  • ???????????? ???? (?????????? ?????????, ???????
    ?????????)
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    ??????????
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    ???????? ??????

16
??????????? ???????? ??????? (???????????)
  • ??????????????? ?????? ?????? ???????????
    ????????, ???? ????????????
  • ???????? ????????? ? ?????, ????????????
    ????????????? ??????
  • ???????? ??????????? ?? ????????? ???????????
    ????????

17
??????????? mini-HTA
  • ?? ???????? ??????????? ??????????????? ????? ?
    ?????? ??????????? ??????????!
  • ????????????? ???? ????? ??????? ???????
    ????????????? ????????????? ?????? ??????????,
    ?? ?? ???????? ??????????!

18
????????? ??????? ??????? ?????????
  • ????????? ???????
  • ?????????????????????? ?????? ??????? ?
    ????????, ???????? ?? ??????????? ???????
    (??????? ? ???????? ??? ??????? ?????????
    ???????).
  • ????????? ? ?????????? ?? ???????-????????????????
    ? ?????? ? ????????? (??? ??????????????
    ????????? ??????? ??? ????????) ?????????????
    ? ??????????? ??????????????.

19
????????? ???????
  • ???????? ??????????? ? ??????? ????????
    ??????????? ? ????????? ????????????? ???????.
  • ???????? ??????????? ? ??????? ????????
    ??????????? ????????????? ??????? ????????????
    ???????? ????.
  • ???????? ??????????? ? ??????????? ???????????
    ??? ?????? ?? ????????????? ?????????????
    ??????? ????????????????? ?????? ????????,
    ???????? ? ????????? ? ???????????? ???????????
    (?), ????????????? ?????????? (?), ???????????
    ??? ?????????? ???????????? ????????? ?????.

20
?????????????? ?????? ??? ???????
  • ?????? 1 ????-?????? ?????????? ??? ????????
    ??????? (??????????????? 2 ????, 1258
    ??????????).
  • ? ?????? ??????? ????????? ????????? ? 36,9
    ????????? (!) ?????? 52,7 ? ?????? ?????????
    ???????.
  • ?????? ?????????????? ????? ??????? ?????????
    ?? 4-? ???????? ?????????? ???????.
  • Ziegler D, Nowak H, Kempler P, Vargha P, Low
    PA. Treatment of symptomatic diabetic
    polyneuropathy with the antioxidant alpha-lipoic
    acid a meta-analysis. Diabet Med. 2004
    Feb21(2)114-21.

21
?????????????? ?????? ????-???????
22
????? ???????????? SYDNEY II
  • ???, ??????? ?????? ? ???????, 181 ????????
  • ????? 5-?????????? ????? ??????? ?????????
    ???????? ? ????? 600 ??, 1200 ??, 1800 ?? ?
    ??????? ????????? ???????????? ?? ????? ?????
    ????????? (Total Symptom Score) ????????? ?
    ??????? ?? 51, 48, 52 ? 32 ?? ?????????
    ?????? ?????????????? (??? ???????? ?????????????
    ???????????)
  • ????????? ????? ????? ????????? ???? ????????
    ?????? ?? ???? ????????? ??????? ? ?????? ????
  • ?????????? ?????????????? ???????

23
????? ???????????? SYDNEY II (2)
24
?????????? ???????
  • ? ????????????? ???????? ??????????????,
    ??????????? ?????????? (????? ???????
    ???????????? ???????? ?????????? ?????????????),
  • ???????????? ?????????? ?? ????? ? ????????? ?
    ?????? ???????
  • ?????????? ???????????? ? ????????????? ?????????
    ?? ???????? ?????????? ?????????.
  • ? ???????????? ?? ?????????? ???????? ? ???????
    ???????? ???????????

25
??????? ? - ??????????? ??? ???????????
????????!
  • ???????? ??????????? ? ??????????? ??????????? ??
    ????????????? ????????????? ???????
    ????????????? ?????????? (?).
  • ???????????? ?????? ???????? ??????
    ??????????????? ????? ?????? ?????? ??
    ?????????? ? ???????????? ??????????????!

26
??????????? ? ?????? ???????????? ????????
  • ? ????????????? ?????????? ??????????? ????????
    ???????????????? ?????? ????????????? ?????????
    ??????? ??? ???????, ????? ?????? ????????? ?
    2008 ????.
  • N Mirza, D Cornblath, S Hasan, U Hussain.
    Alpha-lipoic acid for diabetic peripheral
    neuropathy. The Cochrane Database of Systematic
    Reviews 2005, Issue 4. Art. No. CD005492.
    DOI 10.1002/14651858.CD005492.

27
????????? ????? ?????
  • ?????? ????????????? ????????? ??????????, ??? ??
    ???????????? ? ???????? ??? ?????? ????????????.
  • ?? ??????? ?? ?????????????? ??? ?????????????
    ??? ???? ??????????
  • ??? ?????????? ?????? ? Medline ?????????? 20
    ??????????????? ??????? ?? ?????????????
    ??????????.

28
????????? ??? ???????????
  • ????-?????? ???????????? ?????????????
    ??????????? ??????? (????????? 4 ????????????,
    ? ????????? ??????? 6 ????????????) ??? ??????
    ??????????? - ?? ??????? ????????????? ????, ???
    ?????????? ??????? ??????????? ??????? ? ????????
    ??????????.
  • Seta T, Noguchi Y, Shimada T, Shikata S, Fukui
    T.// European Journal of Gastroenterology and
    Hepatology, 200416(12)1287-1293.

29
????????? ??? ?????? ?????????????? ???????????
  • 2 ???. ?????? ??????? ? ?????????? ?? ??????????
    ????????????? ???? ?? ????? ?? ??????????,
    ?????????? ?????????, ??????? ?????????????
    ??????????? ?????????????, ??????? ?????????
    ?????.
  • T Coats, I Roberts, H Shakur. // The Cochrane
    Database of Systematic Reviews 2004, Issue 4.
    Art. No. CD004896.pub2.

30
????????? ??? ???????? ???????????
??????????????? ?????? ? ????-???????
  • Seta T, Noguchi Y, Shimada T, Shikata S, Fukui
    T.// European Journal of Gastroenterology and
    Hepatology, 200416(12)1287-1293. DARE abstract
    20059090.
  • Heinrich S., Schafer M., Rousson V., Clavien P-A.
    // Annals of Surgery, 2006 243 154-168.
  • T Coats, I Roberts, H Shakur. // The Cochrane
    Database of Systematic Reviews 2004, Issue 4.
    Art. No. CD004896.pub2.
  • Sedrakyan A.// Am J Health-Syst Pharm, 2005 62
    (Suppl 4) S19-23.
  • Levi M., Cromheecke M.E., de Jonge E., et al.//
    Lancet, 1999 354 1940-47.
  • DA Henry, AJ Moxey, PA Carless, D O'Connell, B
    McClelland, KM Henderson, K Sly, A Laupacis, D
    Fergusson. // The Cochrane Database of Systematic
    Reviews 1999, Issue 4. Art. No. CD001886.
  • Fergusson D., Cranley Glass K., Hutton B.,
    Shapiro S. // Clinical trials, 2005 2218-232.
  • Arnold D., Fergusson D., Chan A., Cook R., Fraser
    G., Lim W., Blajchman M., Cook D. // Anesth
    Analg, 2006 102 731-7.
  • PA Carless, DA Henry, AJ Moxey, D O'Connell, B
    McClelland, KM Henderson, K Sly, A Laupacis, D
    Fergusson. // The Cochrane Database of Systematic
    Reviews 2004, Issue 1. Art. No. CD001884.pub2.

31
????????? ??? ???????? ???????????
  • ????????? ???????????
  • ????????? ????? ??????????????
  • (? ??????? ?? 1 ??????????????
  • ??????? 300 ??) ? ?????????
  • ????? ????????? ????????
  • ?????????? ????????????
  • (?? 60 ?? ????????? ? ???????)
  • (????? 62 ????????????).
  • DA Henry, AJ Moxey, PA Carless, D O'Connell, B
    McClelland, KM Henderson, K Sly, A Laupacis, D
    Fergusson. // The Cochrane Database of Systematic
    Reviews 1999, Issue 4. Art. No. CD001886.

32
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  • www.rspor.ru
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