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Ectopic Pregnancy studies

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Ectopic Pregnancy studies This is what we think are the major hurdels: doctors tend to forget about the trial, and women have e strong preference for salpingotoy and ... – PowerPoint PPT presentation

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Title: Ectopic Pregnancy studies


1
Ectopic Pregnancy studies
2
Welcome
3
Introduction
  • ESEP study inclusion
  • Follow up
  • Future
  • Other projects METEX study

4
www.cemach.org.uk
5
MMR EP 0.5/100,000 (1985-2005)
Despite effort, MMR for EP remains static last
20 yrs
6
Alert
  • CEMACH recommendationGuidelines are urgently
    required for the management Pain and bleeding in
    early pregnancy
  • .

June 28th 2010 Invited session 9 Prevention of
maternal death in early pregnancy J. Neilson (UK)
7
EP 1980-2005
2005 1.500 women had surgery for EP 20
laparotomy only 25 salpingotomy
Ref data LMR - Prismant
8
Fertility
9
ESEP study n450
  • P Tubal EP, normale contra lateral tube
  • I Salpingostomy
  • C Salpingectomy
  • O Fertility (time to IUP), repeat EP, PT

10
ESEP study group
11
Inclusion, n299
149
75
62
11
12
May June 2009
13
FINISHED!!! N450
ECTOPIC
THINK ESEP
INCLUDE
INFORMED CONSENT
14
Your hurdles?
?
?
?
http//www.youtube.com/watch?v_rmVkIZnX3U
15
Follow up
  • Serum hCG follow up in both groups until
    undetectable
  • Questionnaires every 6 months
  • Contraceptive use
  • Desire for pregnancy
  • Pregnancy outcome
  • Data base online (www.esepstudy.nl)

16
Dialogue
  • Future esep trial

ESEP
17
EP 1980-2005
Ref data LMR - Prismant
18
  • NNR 450
  • 450-299 151
  • 1500 EPs per year
  • 151/1500 5.2 weeks
  • ESEP inclusion completed!!

15 verschil IUP, Power 80 alpha 5, LFU 10
19
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20
METEX study n 72
  • Ongoing RCT for women with
  • persisting PUL and serum hCG lt 2,000 IU/l
  • or
  • women with an EP and serum hCG lt 1,500 IU/l
  • Expectant management vs single dose MTX
  • Outcomes uneventful decline serum hCG (gt15)
  • quality of life, costs, fertility

www.studies-obsgyn.nl www.metexstudy.nl
21
Inclusions 32!
22
Study information
  • Interested in participation?
  • Eligible patient?
  • www.studies-obsgyn.nl
  • www.metexstudy.nl
  • metex_at_amc.nl

23
(No Transcript)
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