Ectopic Pregnancy studies

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Ectopic Pregnancy studies
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Welcome
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Introduction

• ESEP study inclusion
• Follow up
• Future
• Other projects METEX study

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www.cemach.org.uk
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MMR EP 0.5/100,000 (1985-2005)
Despite effort, MMR for EP remains static last
20 yrs
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Alert

• CEMACH recommendationGuidelines are urgently
  required for the management Pain and bleeding in
  early pregnancy
• .

June 28th 2010 Invited session 9 Prevention of
maternal death in early pregnancy J. Neilson (UK)
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EP 1980-2005
2005 1.500 women had surgery for EP 20
laparotomy only 25 salpingotomy
Ref data LMR - Prismant
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Fertility
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ESEP study n450

• P Tubal EP, normale contra lateral tube
• I Salpingostomy
• C Salpingectomy
• O Fertility (time to IUP), repeat EP, PT

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ESEP study group
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Inclusion, n299
149
75
62
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May June 2009
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FINISHED!!! N450
ECTOPIC
THINK ESEP
INCLUDE
INFORMED CONSENT
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Your hurdles?
?
?
?
http//www.youtube.com/watch?v_rmVkIZnX3U
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Follow up

• Serum hCG follow up in both groups until
  undetectable
• Questionnaires every 6 months
• Contraceptive use
• Desire for pregnancy
• Pregnancy outcome
• Data base online (www.esepstudy.nl)

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Dialogue

• Future esep trial

ESEP
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EP 1980-2005
Ref data LMR - Prismant
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• NNR 450
• 450-299 151
• 1500 EPs per year
• 151/1500 5.2 weeks
• ESEP inclusion completed!!

15 verschil IUP, Power 80 alpha 5, LFU 10
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METEX study n 72

• Ongoing RCT for women with
• persisting PUL and serum hCG lt 2,000 IU/l
• or
• women with an EP and serum hCG lt 1,500 IU/l
• Expectant management vs single dose MTX
• Outcomes uneventful decline serum hCG (gt15)
• quality of life, costs, fertility

www.studies-obsgyn.nl www.metexstudy.nl
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Inclusions 32!
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Study information

• Interested in participation?
• Eligible patient?
• www.studies-obsgyn.nl
• www.metexstudy.nl
• metex_at_amc.nl

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