Physiology of female reproductive system

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Physiology of female reproductive system

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Neonatal period

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Childhood

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• 10?????????
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• 10??????????

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Adolescence or puberty

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• ???? first sexual characteristics
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• secondary sexual characteristics
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• luteinizing hormone,LH
• follicle stimulating hormone,FSH

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Adolescence or puberty

• secondary sexual characteristics
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• Menarche ????
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Sexual maturity

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Peri-menopause

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• 1994?WHO?????????
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• 1?premenopause ????
• 2?menopause ??
• 3?postmenopause ????

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• Premenopause
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• Menopause
• senium praecox??

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Senility

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Menstruation and clinical situation

• Menstruation ??
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• Menarche ????
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• Menstrual cycle ????
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The absence of menstruation
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Menstruation and clinical situation

• The lasting time and the volume of bleeding
• pathologic menstruation VOB gt80ml
• The character of menstrual blood
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Menstruation and clinical situation

• Symptom of menstruation
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• PMS?????
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The functions of ovary and
its periodicit

• The function of ovary
• The periodicit of ovary
• The steroid hormone from ovary
• Polypeptide hormone from ovary

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The functions of ovary and
its periodicit

• The function of ovary
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• The periodicit of ovary
• Ovarian cycle ????
• Follicular development and maturation
• Ovulation
• Formation and degeneration of luteum
• Follicular atresia

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Ovarian periodicit
---Ovarian cycle

• Follicular development and maturation
• Ovulation
• Formation and degeneration of luteum
• Follicular atresia

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Follicular development and
maturation

• Primordial follicle ????
• Oogonium ????
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• Neonatal period 15-50?Follicles
• Sexual maturity
• 300-400?Oogoniums????
• ??????Atretic follicle????

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Follicular development and maturation
---Follicular growth phase

• Primordial follicle ????
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• mature follicle????

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????

• primary follicle?secondary follicle??
• Primary follicle ???????????
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• Secondary follicle
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• ???????,???????????.
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• follicle stimulating hormone,FSH
• estradiol,E2
• testosterone,
• Developing follicle???? ?????????????????(???????
  ??)

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Follicular development and maturation
---Follicular growth phase

• Primitive follicle ????
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• ????
• mature follicle????

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????

• ?FSH???????????
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• ---?????????
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• ---LH?????
• ---Prostaglandin,PG????
• ---Prolactin,PRL????
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Follicular development and maturation
---Follicular growth phase

• Primitive follicle ????
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• ????
• mature follicle????

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Mature follicle

• ??????,??1020mm
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• 1????? 2?????
• 3????? 4????
• 5??? 6????????
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Ovarian periodicit
---Ovarian cycle

• Follicular development and maturation
• Ovulation
• Formation and degeneration of luteum
• Follicular atresia

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Ovulation

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Ovulation

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• ????LH/FSH????
• ??
• E2???????????????
• Gn-RH????????
• ( Gonadotropin releasing horrmone,Gn-RH
• ?????????)
• ?LH/FSH?
• ??????????????????
• ?????????????????

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Ovarian periodicit
---Ovarian cycle

• Follicular development and maturation
• Ovulation
• Formation and degeneration of luteum
• Follicular atresia

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Formation and degeneration of luteum

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• ???7-8????????,9-10?????
• ?????????,??????????????,?????,????,????

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Ovarian periodicit
---Ovarian cycle

• Follicular development and maturation
• Ovulation
• Formation and degeneration of luteum
• Follicular atresia

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Follicular atresia ????

• ???????400?????????????,?????????
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• ????????????????
• ???????????????

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The functions of ovary and
its periodicit

• The function of ovary
• The periodicit of ovary
• The steroid hormone from ovary
• Polypeptide hormone from ovary

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Steroid hormones from ovary

• Structure of steroid hormones
• Biosynthesis of steroid hormones
• Metabolism of steroid hormones
• Mechanism of steroid hormones in use

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Structure of steroid hormones

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• ????19????,??????
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Steroid hormones from ovary

• Structure of steroid hormones
• Biosynthesis of steroid hormones
• Metabolism of steroid hormones
• Mechanism of steroid hormones in use

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Biosynthesis of steroid hormones

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17?-?????
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????? DHEA
17?-???
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Biosynthesis of steroid hormones

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Biosynthesis of steroid hormones

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• ????????17?-???,???????
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Steroid hormones from ovary

• Structure of steroid hormones
• Biosynthesis of steroid hormones
• Metabolism of steroid hormones
• Mechanism of steroid hormones in use

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Metabolism of steroid hormones

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Steroid hormones from ovary

• Structure of steroid hormones
• Biosynthesis of steroid hormones
• Metabolism of steroid hormones
• Mechanism of steroid hormones in use

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Mechanism of steroid hormones in use

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The functions of ovary and
its periodicit

• The function of ovary
• The periodicit of ovary
• The steroid hormone from ovary
• Polypeptide hormone from ovary

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Polypeptide hormone from ovary

• Relaxin ???
• ??????
• ?????????
• ????
• ???????FSH

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Periodicit of endometrium and female genital
organs

• Periodicit of endometrium
• proliferative phase
• secretive phase
• menstrual phase
• Periodicit of other genital organs
• vagina
• cervix
• oviduct

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Hypothalamic-pituitary-ovarian axis
( HPOA) ---???

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• ??
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HPOA

• Gn-RH FSH/LH E/P
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• ????FSH-RH?LH-RH??????????????????,????FSH?LH,????
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• PIH PRL ??
• ?????PIH,??????PRL,?TRH???PRL???
• ????????????

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Regulation of HPOA

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• E (--) FSH-RH
• () LH-RH
• P (--) LH-RH

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Other endocrine glands

• Adrenal glands
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• Thyroid gland
• ?????????HP???
• ???????????????????????

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Prostaglandin

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• ?HP???????,Gn-RH(),LH()
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• ?????????????,??????????????,??????
• PGE????????,???????PGF2a ??????
• ??????

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