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Katie Brown

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Liver Dialysis: Molecular Adsorbents Recirculation System Katie Brown Bme 281 11/27/2012 Problem Being Solved Liver Failure is caused by: Hepatitis B, Hepatitis C ... – PowerPoint PPT presentation

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Title: Katie Brown


1
Liver Dialysis Molecular Adsorbents
Recirculation System
  • Katie Brown
  • Bme 281
  • 11/27/2012

2
Problem Being Solved
  • Liver Failure is caused by
  • Hepatitis B, Hepatitis C, Long term alcohol
    consumption, Cirrhosis, Hemochromatosis,
    Malnutrition, Acetaminophen (Tylenol) overdose,
    reactions to certain prescription and herbal
    medications, Ingestion of poisonous wild
    mushrooms
  • 2000 people die each year while waiting for a
    liver transplant

3
History of Liver Transplants
  • 1728-John hunter, a Scottish surgeon, performed
    animal transplants and tooth transplants
  • 1890-Matheui Jaboulay discovers vascular
    anastomosis with everting sutures
  • 1901- Alexis Carrol implemented animal organ
    transplant using a triangulating vessel technique

4
History (cont)
  • 1963-Tom Starzl performed the first liver
    transplantation
  • 1970s-Starzl and other surgeons 100 executed
    transplantations with 30 success
  • 1996-Stanford split liver transplant
  • 2004- Germany has developed MARS Molecular
    Absorbent Recirculating System

5
Liver
  • Has many functions making it one of the most
    important organs in the body
  • processes digested food from the intestine
    controlling levels of fats, amino acids and
    glucose in the blood 
  • combating infections in the body  clearing the
    blood of particles and infections
  • manufacturing bile
  • stores iron, vitamins and other essential
    chemicals
  • makes enzymes and proteins

6
Current State Molecular Adsorbents Recirculation
System, or MARS
  • The closest we are to a artificial liver
  • Cannot replace a liver, but is a bridge between
    liver failure and transplant
  • How it works
  • Transports a patient's blood to a filter
  • Mixed with a sticky protein called albumin.
  • Toxins in the blood attach to the albumin
    molecules, which then carry the poisons out of
    the blood

7
(No Transcript)
8
Limitations
  • Is not permanent do not replace liver
  • Only last for a short period of time
  • In hospital
  • May have complications-infections
  • Cost for a seven hour treatment 300 for 600 ml
    human serum albumin solution (20), 1740 for a
    MARS treatment kit and 125 disposables used by
    the dialysis machine have to be spent

9
Future
  • More like a liver
  • Lower Cost
  • Longer lasting
  • Portable
  • artificial liver

10
Works Cited
  • Busuttil RW, Goss JA. Split liver
    transplantation. Ann Surg. 1999229313321.
  • Khuroo MS, Farahat KL. Molecular adsorbent
    recirculating system for acute and
    acute-on-chronic liver failure a meta-analysis.
    Liver Transpl 2004 10 1099-1106.
  • Johnson, Kimball. "Liver Failure." Web MD. Web
    MD, 11 2012. Web. 20 Nov 2012.
  • Cohen, Jamie. "New Artificial Liver Shows
    Promise." ABC News. ABC News, 17 2012. Web. 20
    Nov 2012.
  • "Molecular Adsorbent Recirculating System."
    Therapies. Gambro, 2011. Web. 20 Nov 2012.
  • "A Brief Summary of the Liver's Functions."
    Fighting Liver Disease. British Liver Trust,
    2011. Web. 20 Nov 2012.
  • "Liver Dialysis Unit." Fighting Liver Disease.
    Hepatitis Central, n.d. Web. 20 Nov 2012.
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