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IMMUNOGLOBULIN STRUCTURE AND FUNCTION

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IMMUNOGLOBULIN STRUCTURE AND FUNCTION September 20, 2006 THE TWO FORMS OF ANTIBODY Membrane form is on the surface of B cells Plasma cells make the secreted form ... – PowerPoint PPT presentation

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Title: IMMUNOGLOBULIN STRUCTURE AND FUNCTION


1
IMMUNOGLOBULIN STRUCTURE AND FUNCTION
September 20, 2006
2
THE TWO FORMS OF ANTIBODY
Membrane form is on the surface of B cells
Plasma cells make the secreted form which is
found plasma, lymph, and interstitial fluid.
The secreted form can also be found on the
surface of cells with FcR
3
IMMUNOGLOBULINS HAVE 4 POLYPEPTIDE CHAINS
2 Identical H(eavy) chains 2 Identical L(ight)
chains
4
HEAVY AND LIGHT CHAINS HAVE VARIABLE AND CONSTANT
REGIONS
5
ANTIBODY MOLECULES HAVE GLOBULAR REGIONS
The globular regions are separated by a hinge
region
The globular regions contain globular domains
6
THE STRUCTURE OF THE DOMAINS PROVIDES STABILITY
Domains are approximately 110 amino acids
Amino acids are aligned in b sheets
V and C are slightly different
7
ANTIBODY MOLECULES CAN BE CLEAVED BY PROTEOLYTIC
ENZYMES
Cleavage separates functionally distinct parts of
protein
8
Figure 3-4
HINGE REGION PROVIDES FLEXIBILITY
Electron micrographs of ag-ab interaction
demonstrates flexibility
9
WU AND KABAT PLOTS REVEAL REGIONS OF
HYPERVARIABILITY
10
HYPERVARIABLE REGIONS ARE LOCATED IN DISCRETE
LOOPS
11
AN ANTIBODY BINDS AN EPITOPE OF THE ANTIGEN
Antibody molecule binds epitopes on a viral
particle
12
Figure 3-8
Antigen Binding Site Can Have Different Shapes
4 types pocket, groove, extended surface and
protruding surface
13
THE DIFFERENT CLASSES OF ANTIBODY
There are two types of L chain k and l
There are 5 types of H chain g, m, d, a, e
A complete antibody molecule has 2 identical
light chains and 2 identical heavy chains
14
EACH ISOTYPE HAS SPECIFIC PROPERTIES AND FUNCTIONS
15
IgM AND IgA CAN FORM MULTIMERS
16
ANTIGENIC PROPERTIES OF IMMUNOGLOBULINS
17
Isotypes have selective distribution
18
POLYMERIC ISOTYPES CAN BE TRANSCYTOSED
19
BACTERIA CAUSE DISEASE BY SECRETING TOXINS
20
High Affinity IgG and IgA Can Neutralize Toxins
21
High Affinity IgG and IgA Can Inhibit Viral
Infection
22
Ig Can Block Adherence of Bacteria
IgA at mucosal surfaces IgG at other sites
23
OPSONIZATION (IgG and IgA)
Opsonization requires matching between FcR and Ig
24
ADCC(IgG)
ADCC also requires FcR and Ig isotype matching
25
MAST CELL DEGRANULATION (IgE)
26
FUNCTION AND DISTRIBUTION OF Ig ISOTYPES
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