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Chapter 10 Cell Growth

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Chapter 10 Cell Growth & Division Section 10-3 Regulating Cell Growth Controls On Cell Division When Cells In Cell Cultures Come In Contact With Each Other, They Stop ... – PowerPoint PPT presentation

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Title: Chapter 10 Cell Growth


1
Chapter 10 Cell Growth Division
  • Section 10-3
  • Regulating Cell Growth

2
Controls On Cell Division
  • When Cells In Cell Cultures Come In Contact With
    Each Other, They Stop Growing.
  • Why?

3
Controls On Cell Division
  • If A Hole Is Made In The Cell Culture, Cell
    Growth Will Restart Continue Until The Hole Is
    Filled.
  • Why?

4
Controls On Cell Division
  • In Your Body The Rate Of Cell Growth Is
    Controlled.
  • Injury Causes Rapid Division Until The Wound Is
    Healed. Then Division Slows Again.
  • Why?

5
Cell Cycle Regulators
  • Key Concept
  • Cyclins Regulate The Timing Of The Cell Cycle In
    Eukaryote Cells.
  • Discovered In The 1980s
  • Cyclins Are A Family Of Closely Related Proteins
    That Rise Fall Within The Cell With The Cell
    Cycle

6
Cyclins Cell Cycle
7
Cell Cycle Regulators
  • Cyclins
  • When Injected Into Non-Dividing Cells, Cyclins
    Cause Mitotic Spindles To Form.

8
Cell Cycle Regulators
  • Cyclins
  • When Injected Into Non-Dividing Cells, Cyclins
    Cause Mitotic Spindles To Form.

9
Cell Cycle Regulators
  • Cyclins
  • When Injected Into Non-Dividing Cells, Cyclins
    Cause Mitotic Spindles To Form.

10
Cell Cycle Regulators
  • Other Regulator Proteins Continue To Be Found.

11
Other Internal Regulators
  • These Proteins Respond To Events Inside The Cell.
  • Several Make Sure The Cell Does Not Enter Mitosis
    Until All Chromosomes Have Been Replicated.
  • Others Stop The Cell From Entering Anaphase Until
    All Chromosomes Are Attached To The Mitotic
    Spindle

12
Cyclins Cell Cycle
13
External Regulators
  • These Respond To Events Outside The Cell
  • They Direct The Cell To Speed Up Or Slow Down The
    Cell Cycle
  • These Include Growth Factors

14
Growth Factors
  • Very Active During
  • Embryonic Development
  • Wound Healing

15
Other External Regulators
  • Molecules On The Cell Membrane Of Neighboring
    Cells Slow The Growth Process
  • They are like sensors that signal the cell to
    slow/stop growth

16
Uncontrolled Cell Growth
17
Uncontrolled Cell Growth
  • Key Concept
  • Cancer Cells Do Not Respond To The Signals That
    Regulate The Growth Of Most Cells. As A Result,
    They Form Masses Of Cells Called Tumors That Can
    Damage Surrounding Tissue.

18
Uncontrolled Cell Growth
  • Metastasis
  • Cancer Cells Break Loose From The Tumor And
    Invade Tissues Throughout The Body

19
Some Carcinogen Sources
  • Smoking
  • Radiation
  • Viral Infection

20
p53 Gene
  • Usually Stops The Cell Cycle Until Chromosomes
    Have Been Properly Replicated.
  • High Percentage Of Cancers Cells Have Defects At
    This Gene Site
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