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MBP 1018Y: Oncology

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Title: How to Craft a Well-Written Grant Proposal Author: msukhai Last modified by: dsears Created Date: 12/11/2006 6:18:20 PM Document presentation format – PowerPoint PPT presentation

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Title: MBP 1018Y: Oncology


1
MBP 1018Y Oncology
  • Wednesdays, 10 a.m. 12 noon
  • January 11 May 02, 2012 inclusive
  • 610 University Avenue, Room 7-605

2
Outline
  • Introductions
  • Course Contact Information
  • Significant Dates
  • Course Schedule
  • Course Overview Goal, Format
  • Course Evaluation
  • Tutorial Schedule
  • Tutorial

3
Contact Information
  • Course Coordinator Dr. Brad Wouters
  • Room 10-116, Princess Margaret Hospital
  • 610 University Avenue
  • Tel 416-581-7840
  • E-Mail bwouters_at_uhnresearch.ca
  • Teaching Assistant Dr. Mahadeo Sukhai
    (Day-to-day contact person)
  • Room 9-620, Princess Margaret Hospital
  • 610 University Avenue
  • Tel 416-946-4501 x 3498
  • Email m.sukhai_at_utoronto.ca

4
Significant Dates
Date Deliverable
January 11 Introductory session
January 25 Submission of abstract of thesis project term project groups identified and topics selected
February 08 Submission of midterm assignment
April 04 Last session
April 11 Oral presentations part 1
April 18 Oral presentations part 2
April 25/May 02 Submission of final assignment
5
Course Schedule 2012
DATE TOPIC LECTURER
JAN. 11 Introduction M. Sukhai
JAN. 18 Imaged based monitoring of individual response to treatment G. Czarnota
JAN. 25 The importance of genetic variation in oncology G. Liu
FEB. 01 Novel models and methods for assessment of new targeted agents in oncology D. Hedley
FEB. 08 Lung cancer genomics and patient individualization M. Tsao
FEB. 15 Image guided personalized therapy D. Jaffray
FEB. 22 Personalized Immunotherapy Approaches N. Hirano
FEB. 29 Novel targeted drugs and their introduction in the clinic P. Bedard
MAR. 07 Tumor microenviornment and metabolism in radiation oncology M. Milosevic
MAR. 14 Novel risk factors N. Boyd
MAR. 21 Breast cancer oncogenesis and new targets M. Reedjik
MAR. 28 Imaging in oncology G. Stanisz
APR. 04 Novel targets in leukemia M. Minden
APR. 11 Oral Presentation Class
APR. 18 Oral Presentation Class
APR. 25 Oral Presentation / Optional Tutorial Session Class
MAY 02 Final Assignment Due
6
Course Goals
  • To expose graduate students to the concepts of
    translational oncology (from bench to bedside)
    through a series of seminar-type presentations
    highlighting recent advances of translational
    research
  • And,
  • To motivate graduate students to apply the
    concepts of translational oncology to their own
    research through a series of written and oral
    assignments.

7
Course Format
  • Didactic lectures
  • 12 sessions, led by experts in the field (1 hr
    each)
  • Theme Personalized medicine
  • Journal Clubs
  • 12 sessions, held after each lecture (1 hr each)
  • Group term project development and presentation
    of program project grant proposal

8
Class Format
  • Part 1 Didactic lecture, followed by
    discussion/QA (1 hr)
  • Class discussion on 1-2 papers chosen by
    lecturer, led by students (Journal Club 1 hr)

9
Journal Club Format
  • Each lecturer (and their papers) will be assigned
    to teams of students (2-3 students per team)
  • Student teams to lead class discussions

10
DOs
  • Focus on big picture implications of the
    papers integration with earlier concepts in the
    course impact on personalized medicine what
    comes next?
  • Engage all students in the discussion
  • Spread the facilitation duties around among the
    team
  • Keep discussion lively and interesting be
    creative

11
How do we keep the discussion going?
  • Facilitate!
  • Be creative
  • Mock debates (pro/con)
  • Plant ringers
  • Play games with the audience
  • Snap group discussions
  • The skys the limit
  • For advice and assistance, contact the TA

12
Do NOTs
  • Rely on Powerpoint presentations
  • Dissect/critique the papers, figure by figure
  • Monopolize the discussion
  • Fail to engage your classmates

13
Every students responsibility
  • Read the papers
  • Even if youre not presenting them!
  • Come prepared with discussion questions to keep
    the journal club lively
  • Evaluate the success of the discussion
  • Integrate the knowledge gained/insights into your
    term projects and (beyond the course) research

14
Course Evaluation
  • Participation (20)
  • Class attendance (if you are unable to attend
    with reason, please notify Dr. Sukhai in advance)
  • Leadership of journal club
  • Participation in journal club
  • NOTE that each weeks lecture/journal club will
    be evaluated through student survey feedback
  • Midterm Assignment (15)
  • Term Paper (50)
  • Oral Presentation (15)

15
Lecture Attendance
  • MANDATORY
  • If you are unable to attend (for e.g., ill
    committee meeting conference), please notify Dr.
    Sukhai
  • My experiment got in the way is not an
    acceptable excuse (speaks to time management
    skills)
  • I needed to finish my assignment for X course
    is also not an acceptable excuse

16
Term Projects
  • Group-developed program project grant
    application
  • Midterm Individual letters of intent
  • Final Group project proposal
  • Oral Group presentation of project proposal
  • In these types of grants, often three to four
    linked initiatives are submitted as part of a
    larger overall program of research.
  • For example, a program project grant in head and
    neck cancer may involve biomarker identification
    and validation imaging and new therapy
    development, all linked by common themes and
    integrated with one another.
  • Demonstrates team science and the ability to
    integrate concepts and ideas in a collaborative
    environment

17
Term Projects
  • Groups of 3-4
  • Each group identifies an overall topic or theme
  • MUST be approved by Dr. Sukhai
  • No two groups can do the same topic
  • Topic choice is made on a first come-first served
    basis
  • Whats a topic/theme? Examples
  • A given tumor site
  • Multiple approaches to biomarker
    discovery/validation
  • Novel target discovery/experimental therapeutics
  • Combinations of the above
  • Anything you can think of!

18
Midterm Assignment
  • Letter-of-intent/Statement of Research
    Interests
  • INDIVIDUAL SUBMISSION
  • 2 pages
  • Single spaced
  • Not including any necessary references or the
    title page
  • Contents
  • Clearly stated research question
  • Well-defined hypothesis
  • Two clearly-stated aims/objectives
  • Translational relevance
  • Human impact
  • Integration with overall group project
  • Set the Stage for your final assignment
  • Each group is also expected to submit an overall
    group abstract, outlining the parts of the group
    project application

19
Midterm Assignment
  • What is NOT necessary
  • Detailed methodology
  • Discussion of experimental plan
  • DO NOT make this about your research directly!

20
Midterm Assignment Research Plan
  • Set the Stage
  • Background of your question
  • Clinical and translational relevance
  • Rationale for your choice
  • What models and systems will you be using
  • You may outline your proposed study design, but
    dont make this the focus of your discussion

21
Midterm Assignment Research Plan
  • Why are we making you do this?
  • Experience with a different style of scientific
    writing
  • Grad students, post-docs and people applying for
    faculty positions have to write these statements
    of research interest in applying for
    fellowships/positions
  • Write for a general audience OK to be
    nontechnical
  • Good practice to solidify your ideas before
    launching into the more complex and technical
    grant writing exercise

22
Term Paper
  • Medical Biophysics Translational Research
    Program Project Grant
  • Full research proposal
  • 4 pages per group member
  • Single spaced
  • Not including figures, tables, references, title
    page
  • This grant is to be built around the
    translational research aim(s) you designed for
    the Midterm Assignment

23
Final Assignment Grant Proposal
  • Longer and more complex than the research plan
  • Similar to grant and fellowship proposals you
    will be writing as a graduate student
  • Similar to the design for a reclass/qualifying
    exam proposal
  • Intended to give you a sense of the form and
    function in a scientific proposal
  • Meant to be a window into your thought
    processes if well written

24
Term Paper
  • Components
  • Abstract of overall project (1 page)
  • Introduction and statement of relevance (2 pages)
  • Rationale and outline of objectives/hypotheses (1
    page)
  • Each group members specific research proposal (4
    pages, max, each including a review of
    preliminary data from the literature, 2 aims, and
    a statement of translational implication)
  • A section on integration and an overall
    conclusion (1 page)

25
Oral Presentation
  • Group (25-30 minute) oral presentation outlining
    your research proposal
  • Focus on translational aims and impact
  • Interview for grant proposal

26
Assignment Notes
  • Late papers will not be accepted
  • Electronic submissions are preferred
  • Your research question CANNOT be derived from
    your own work
  • To verify this, we ask for a copy of your
    research abstract (e.g., your project proposal
    abstract from your first committee meeting or
    qualifying/reclassification exam or your student
    seminar abstract)
  • Failure to abide by this rule will result in an
    automatic failing grade in the course there will
    be no opportunity for a make-up assignment
  • You may stay within the same disease, but you
    must choose a different aspect of it (for e.g.,
    if you are working on a particular signaling
    pathway, you cannot do that, but you can do
    something based on imaging modalities in the same
    disease, or experimental therapeutics, etc.)
  • You cannot work on the same protein
  • You may apply a technique youre learning or
    working on currently to your research question,
    but remember that a research question isnt based
    around a technique
  • You can, also, if you like, extrapolate from your
    research if it is very basic, and consider how
    you would apply it 5 or 10 years from now, in the
    clinical setting
  • If you have any questions, please do not hesitate
    to contact Dr. Sukhai

27
What is Translational Research?
  • For the purposes of this grant, Translational
    Research is defined to be use of clinically
    obtained samples in at least one major aim of the
    proposal
  • Specifically, use of
  • Human subjects (with malignancy or disease)
  • Primary tissues/fluids (e.g., bone marrow samples
    or tumour biopsies) derived from patients with
    malignancy or disease
  • You CANNOT use for this purpose
  • Mice or other animal models
  • Cell lines derived from patients
  • Other cell culture systems

28
But I Dont Do Translational Research!
  • Dont worry! Fewer of us than you might think do
    purely translational research
  • Objective of MBP 1018 is to develop your ability
    to conceive of and integrate translational
    concepts into your thinking
  • If you do
  • Basic research (with cell lines or animal models)
  • Structural research
  • Photonics or imaging research
  • There are translational applications in the
    future just think about them!

29
But I Dont Do Oncology Research!
  • Thats OK think about the pathways you work on.
  • Do they have application to cancer in some way?
  • Can you draw connections outside of your own
    immediate sphere of research?
  • If you can, write about those connections.

30
Tutorial Scheduling and Purpose
  • Tuesdays, 4-5 p.m.
  • 610 University Avenue, room 7-605
  • Purposes
  • Forum for learning to improve your scientific
    writing
  • Forum for dealing with necessary course business
  • Whatever else you want them to be
  • My formal office hours

31
Tutorial Schedule
DATE TOPIC
Jan. 17 Effective group facilitation getting the most out of the journal club discussions
Jan. 24 QA around term project topics
Jan. 31 Short-form proposal abstract/Letter of Intent writing
Feb. 07 QA on Midterms
Feb. 14 Topic of students choice
Feb. 21 Topic of students choice
Feb. 28 Midterm Feedback
Mar. 06 Writing long-form proposals I
Mar. 13 Writing long-form proposals II
Mar. 20 Requirements for the Oral Presentation
Mar. 27 Writing long-form proposals III
April 03 QA on Orals
April 25 QA on Final Assignments
32
Tutorial 1 Analysis of Primary Papers
  • Rules of Reading a Paper
  • Things to look for

33
CRITICAL READING
2 Rules
34
Rule 1
Read the paper
35
Rule 1b
Read all of the paper
36
Rule 2
Look at the data
37
Critical Points
  • Understand the details of the research
  • Initial observations/background
  • Formulate the question/problem
  • Is there a hypothesis?
  • Is the methodology valid?
  • Is the experiment appropriate?
  • Are the data of high quality?
  • Are the appropriate controls present?
  • Are the data consistent with other data?

38
Discussion Points
  • Understand the details of the research
  • Initial observations/background
  • Formulate the question/problem
  • Is there a hypothesis?
  • Is the methodology valid?
  • Is the experiment appropriate?
  • Are the data of high quality?
  • Are the appropriate controls present?
  • Are the data consistent with other data?

39
Things to look for
  • Was the methodology appropriate for the question
    being asked?
  • Were the data consistent with the methodology?
  • Were the data internally consistent?
  • Do the data make sense?
  • Were the controls appropriate?
  • Can you conclude what the authors concluded from
    their data?
  • Do you agree/disagree with the authors
    interpretation?
  • Do you agree with the big picture the authors
    present?

40
The Matrix
GOOD WRITING GOOD SCIENCE GOOD WRITING BAD SCIENCE
BAD WRITING GOOD SCIENCE BAD WRITING BAD SCIENCE
41
Questions?
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