Steric Effects

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Steric Effects
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Effect of Nucleophile Strength on Reaction Rate
Across a period CH3- gt NH2- gt OH- gt F-
Nucleophilicity Strongest
---------------------- Weakest Basicity
(Bronsted) Strongest -----------------------
Weakest Down a group F- gt Cl- gt Br- gt
I- aprotic solvent
Nucleophilicity Strongest ----------------------
Weakest Basicity (Bronsted)
Strongest ----------------------- Weakest I- gt
Br- gt Cl- gt F- protic solvent (H bonds)
Nucleophilicity Strongest
----------------------- Weakest
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