A preliminary model for the role of the basal ganglia in natural motor control and motor programming

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A preliminary model for the role of the basal
ganglia in natural motor control and motor
programming
MURI Meeting, June 4th, 2002Steve Massaquoi,
Zhi-Hong Mao, Eugene Lim, Munther Dahleh, and
Eric FeronMassachusetts Institute of Technology
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Modeling the lower (motor) loop of the basal
ganglia in movement

• Our model produced reasonable representations of
  normal and abnormal basal ganglionic functions in
  lower loop
• Cruise movement generation
• Dysfunctions in Parkinsons disease and dystonia

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Proposed role of the basal ganglia in regulating
cruise movement velocity
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Model simulator structure
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Dysfunction of the basal ganglia in Parkinsons
disease

• Signs of Parkinsons disease
• Tremor at rest
• Slowness of movement (bradykinesia)
• Rigidity of body

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Model simulator structure
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Dysfunction of the basal ganglia in dystonia

• Signs of dystonia
• Abnormal posture and tremor

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Model simulator structure
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Modeling the lower (motor) loop of the basal
ganglia in movement

• Our model produced reasonable representations of
  normal and abnormal basal ganglionic functions in
  lower loop
• Cruise movement generation
• Dysfunctions in Parkinsons disease and dystonia

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Role of the higher (cognitive) loop of the basal
ganglia in programmed behavioral tasks

• Conflict resolution over access to limited
  cognitive resources
• Switching, brain states transition, and sequence
  generation
• Circuit in higher loop is the same as in lower
  loop
• A toy example

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Conclusions and future work

• Conclusions
• The model is very simple
• The model is consistent with the neuronal anatomy
  of the basal ganglia
• The same circuit in the model is able to control
  cruise movement, to reproduce signs in the
  Parkinsons disease and dystonia, and to execute
  programmed behavioral tasks
• Future work
• Self tuning (learning) through reinforcement
• Learning cooperative behavior