?????(Paraneoplastic syndrome):??????(PHC)??????????????????????????????????,??????????????????????????????,?????????????????? - PowerPoint PPT Presentation

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?????(Paraneoplastic syndrome):??????(PHC)??????????????????????????????????,??????????????????????????????,??????????????????

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Paraneoplastic syndrome PHC ... – PowerPoint PPT presentation

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Title: ?????(Paraneoplastic syndrome):??????(PHC)??????????????????????????????????,??????????????????????????????,??????????????????


1
??????????
2
??
  • ?????(Paraneoplastic syndrome)??????(PHC)????????
    ??????????????????????????,???????????????????????
    ???????,??????????????????
  • ??????????????????,????????????(APUD??),?????????
    ????,??????????,?????5-????????,??????????????????
    ?????????,????????
  • PHC????????10?,???????????????1.????????
    2.?????? 3.????

3
?. ????????
4
??????????????
  • ????????????????????,?Luo-Jc???1197?????232???????
    ????(19.4)
  • ????????? ?????? ???? ???????????
  • ????????????,?????????????Luo-Jc?????????????????
    ?(gt?????30)??AFP????????????????????????????????

5
1?????
  • PHC?????????,???????10 30
  • ?????????????????????????????????lt2.8mmol/L
  • Mcfadzean??
  • A???????,???????????,??????,????
  • B????????,???????????,??????,????
  • ??
  • ?????????????????????????(Insulin growth factor
    ?,IGF- ?)
  • ????????-6-??????????,????????????
  • ???????????,????????????????

6
2???????
  • PHC????????,???2 10,??????
  • ????
  • ?? RBC gt6.51012 Hbgt170g/L RBC??gt0.52
  • ?? RBC gt6.01012 Hbgt160g/L RBC??gt0.47
  • (?????????????)
  • ???????????????,?????????????????????
  • ??
  • ????????????????,???????????
  • ??????????,??????
  • Brownstein??,??????????????????????,??????????

7
3?????
  • ??gt2.9mmol/L,?PHC???????,?????????,???????????????
    ?????815
  • ??????????????????????????????????
  • ??
  • ??????????????,?????,??????
  • ?????????D???,????????
  • ????????????(OAF),??????

8
4????????????
  • ???50?????,????????38
  • ??
  • ??????????????,????????
  • ????HMG-COA??????????,???????????
  • ???????????,????,??????????????????

9
5????????????????
  • ????1 Geoffrey?????????????????????????6???????,?
    ????????????????,?????ACTH????,CT????????????????A
    CTH???????ACTH?????????????????????????ACTH?????

10
  • ????2 Uwe JF?????????????????,???????????T4???TBG
    (thyroxine-binding globulin,?????????)??,???TBG???
    ?ALT????????????????????

11
  • ????3 Hirotaka Arai??????????????,??????????????
    ????????????????????(?????????????)???????????????
    ???????,????ACE???????????????????????

12
  • ?????????????????????????????????????

13
?????????????
  • ????1Uwe JF????????????????,???IGF- ???????,
    ?IGF- ??????? IGF- ??(big IGF- ?
    propetide)??????,???IGF- ????????IGF-
    ?????????IGF- ????????????????????????????????????
    ??

14
????????
15
????????????
  • ???????????????????????(Chronic sensormotor
    polyneuropathy and polymyositis),?????????????????
    ??????
  • ???????????????????,??????????????????????,???????
    ????????
  • ?????????????????????

16
???????????
  • ?????????????????????????,???????????????????????
    ???,????????????????????????????????,????????????
    ???IgG??,???????
  • ??????????Norris-s?????????????(????????????),???
    ??????????????????????????????

17
??????
18
?????
  • ??????????????,???????????????T.OCHIAE???????????,
    ????????????????????????????,???????????
  • ??????????????,d-?????????( d-amionlevalinic
    acid,ALA synthase),ALA????????????????????????????
    ?????????????????

19
??
  • PHC?????????????????????,?????????????????
  • ??
  • ??PHC???????????
  • ?????????,?????????,????
  • ?????????,????????,??????,????

20
???? Thank You
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