DNA Replication and Repair

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Chapter 20

• DNA Replication and Repair

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Replication is bidirectional
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DNA Replication is Semidiscontinuous
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Okazaki Fragments
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DNA Polymerase III is a Multisubunit Enzyme
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DNA Polymerase III Subunit Organization
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DNA Replication is a Processive Process.
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Stages of DNA Replication

• Initiation
• Elongation
• Termination

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PCNA analogous to E. coli b-subunit of E. coli
DNA polymerase
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Repair of UV Induced Thymine Dimers
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Repair of damage resulting from the deamination
of cytosine